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Previous Year Questions

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TLS Online TPP Program

QUESTION ID:1

In Drosophila, balancer chromosomes are used to keep all the alleles on one chromosome together. A balancer contains multiple inversions; so that when it recombines with the corresponding wild type chromosome, no viable cross over products are formed. Balancers also carry an allele for a dominant phenotype.
A Drosophila male with sepia eye color Is crossed to a female carrying a third chromosome balancer (TM&B). The allele for sepia phenotype (se) is located on chromosome 3 and is recessive to the wild type eye color. The dominant marker for TM&B is a tubby phenotype. Further, an Individual homozygous for TM&B balancer does not survive. F1 progeny with tubby phenotype Is sib-mated.
The F2 progeny Is expected to have:

QUESTION ID:2

The following statements are made about mammalian development:
A. Zygote is a totipotent stem cell.
B. The cells of Inner cell mass are said to be pluripotent.
c. The three regulatory transcription factors, Oct4, Nanog and Sox2 help maintain pluripotency of the inner cell mass.
D. Cdx2 upregulates Oct4 and Nanog.
Which one of the following options represents the correct combination of the statements?

QUESTION ID:3

Excision repair systems replace a short stretch of DNA around the site of damage. The following statements are made about nucleotide excision repair In E. coli:
A. UvrB homodimer creates the nicks on one strand on both side of the lesion.
B. The 50-60 residue-long stretch of DNA between the two nicks Is removed by the action of UvrD.
c. The gap generated is filled in typically by DNA polymerase I.
D. The distortion caused by the lesion Is recognized and bound by uvrA-UvrB complex.
Which one of the following options represents the combination of all correct statements?

QUESTION ID:4

Given below are some statements about pituitary hormones:
A. Oxytocin and vasopressin are synthesized In posterior pituitary
B. Prolactin is synthesized from anterior pituitary
C. a and II MSH are secreted from Intermediate lobe or pituitary In adult humans
D. Growth hormone secretion from anterior pituitary is stimulated by hyperglycemia
E. Prolactin secretion Is markedly Increased by sleep
Choose the INCORRECT combination of statements from below:

QUESTION ID:5

Mouse lgM (whole molecule) was injected into rabbit to generate antiserum. Which one of the following mouse antibody components (the same mouse from which IgM molecules were used for Immunization) has the possibility to be recognized using the rabbit antiserum in Western blotting?

QUESTION ID:6

In eukaryotes, DNA replication must occur with extreme accuracy and only once to prevent the damaging effects of gene amplification. The following statements were made regarding possible mechanisms Involved In achieving tight regulation of DNA replication:
A. High APC/C activity In mitosis and early G1 phase of the cell cycle that triggers the destruction of Cdt1 Inhibitor geminin, thus allowing Cdt1 to be active In early G1 to load helicases.
B. Activation of S-Cdks that regulate the phosphorylation of specific Initiator proteins In the 5-phase.
c. MCM helicase loads at the s-phase of the cell cycle, so that replication begins only at s-phase.
D. Cdc6 and Cdt1 bind to the origin recognition complex (ORC) and help In pre-replicative complex assembly only after mitosis.
Which one of the options has all correct statements?

QUESTION ID:7

The intake of nutrients is under intricate control. A number of statements are made about factors controlling food intake:
A. Cholecystokinin produced from small Intestine stimulates food Intake
B. Leptin produced in adipose tissues stimulates food intake
C. Leptin receptors are located In hypothalamus
D. Ghrelin produced in the stomach inhibits food intake
E. Leptin also stimulates the metabolic rate
F. Ghrelin increases secretion of Neuropeptide Y
Choose the combination of all correct statements from the following options

QUESTION ID:8

The diffraction patterns of two forms of DNA (A and B) and statements related to these patterns are given below.

A. The diffraction pattern corresponding to A-DNA is shown by form 1 with 11.6 base pairs per turn.

B. The diffraction pattern of B-DNA Is shown by form 2 with 11.6 base pairs per turn.

c. The diffraction pattern of A-DNA is shown by form 2 with 11.6 base pairs per turn.

D. The diffraction pattern of B-DNA Is shown by form 1 with 10 base pairs per tum.

Which one of the following options have all correct statements?

QUESTION ID:9

Following statements were made about chromatin remodeling in eukaryotes:
A. Chromatin remodeling completely alters and/or slides the nucleosome, but cannot displace it.
B. Chromatin remodeling Is an energy driven, developmentally regulated active process.
c. Histone acetylation is a reversible process, in which each direction of the reaction is catalyzed by different enzymes.
D. In general, acetylation of core histones reduces their affinity for DNA and destabilizes the chromatin structure, causing transcriptional repression.
E. Phosphorylation or Ser1of histone H2A has been associated with transcription repression.
Which one of the following represents the combination of correct statements?