Menu

Previous Year Questions

TLS Online TPP Program

QUESTION ID:1

In eukaryotes, DNA replication must occur with extreme accuracy and only once to prevent the damaging effects of gene amplification. The following statements were made regarding possible mechanisms Involved In achieving tight regulation of DNA replication:
A. High APC/C activity In mitosis and early G1 phase of the cell cycle that triggers the destruction of Cdt1 Inhibitor geminin, thus allowing Cdt1 to be active In early G1 to load helicases.
B. Activation of S-Cdks that regulate the phosphorylation of specific Initiator proteins In the 5-phase.
c. MCM helicase loads at the s-phase of the cell cycle, so that replication begins only at s-phase.
D. Cdc6 and Cdt1 bind to the origin recognition complex (ORC) and help In pre-replicative complex assembly only after mitosis.
Which one of the options has all correct statements?

QUESTION ID:2

The intake of nutrients is under intricate control. A number of statements are made about factors controlling food intake:
A. Cholecystokinin produced from small Intestine stimulates food Intake
B. Leptin produced in adipose tissues stimulates food intake
C. Leptin receptors are located In hypothalamus
D. Ghrelin produced in the stomach inhibits food intake
E. Leptin also stimulates the metabolic rate
F. Ghrelin increases secretion of Neuropeptide Y
Choose the combination of all correct statements from the following options

QUESTION ID:3

The diffraction patterns of two forms of DNA (A and B) and statements related to these patterns are given below.

A. The diffraction pattern corresponding to A-DNA is shown by form 1 with 11.6 base pairs per turn.

B. The diffraction pattern of B-DNA Is shown by form 2 with 11.6 base pairs per turn.

c. The diffraction pattern of A-DNA is shown by form 2 with 11.6 base pairs per turn.

D. The diffraction pattern of B-DNA Is shown by form 1 with 10 base pairs per tum.

Which one of the following options have all correct statements?

QUESTION ID:4

Following statements were made about chromatin remodeling in eukaryotes:
A. Chromatin remodeling completely alters and/or slides the nucleosome, but cannot displace it.
B. Chromatin remodeling Is an energy driven, developmentally regulated active process.
c. Histone acetylation is a reversible process, in which each direction of the reaction is catalyzed by different enzymes.
D. In general, acetylation of core histones reduces their affinity for DNA and destabilizes the chromatin structure, causing transcriptional repression.
E. Phosphorylation or Ser1of histone H2A has been associated with transcription repression.
Which one of the following represents the combination of correct statements?