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Previous Year Questions

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TLS Online TPP Program

QUESTION ID:1

Choose the correct form of verb to fill in the blank:

Risks come from not what you are doing?

QUESTION ID:2

Choose the appropriate preposition to complete the sentence:

Her request for a transfer was turned

QUESTION ID:3

Pick out the correctly spelt word.

QUESTION ID:4

Identify the correct indirect speech of the following sentence.

He said to me, "I don't believe you"

QUESTION ID:5

Rearrange the following parts of a sentence labelled PQRS to make a meaningful sentence.
P. overflow of powerful
Q. recollected in spontaneous
R. Poetry is a spontaneous
S. feelings emotions

QUESTION ID:6

Pick out the antonym of 'strength'

QUESTION ID:7

Choose the correct sentence.

QUESTION ID:8

Choose the correct passive voice form of the following sentence.

He may have eaten the cake.

QUESTION ID:9

Pick out the synonym of the following word - 'captivating'.

QUESTION ID:10

Identify the part of speech of the underlined word in the following sentence.

Let us even the ground.

QUESTION ID:11

Who has been appointed as the new chief economic advisor (CEA) to the Government of India?

QUESTION ID:12

Which of the following companies are among the recently created 7 new Defence Public Sector Undertaking Companies, which were created through restructuring of OFB (Ordiance Factory Board) ?

A. Weapons India Limited
B. Munitions Indian Limited
C. Yantra India Limited
D. Gliders India Limited

Choose the correct answer from the options given below:

QUESTION ID:13

Name of the autobiography of Kamala Das is :

QUESTION ID:14

Who among the following is the first woman to receive two Nobel Prizes ?

QUESTION ID:15

In a certain code language

"uo ja ka hu" means 'we great Indian country',
"oi ka la ju" means 'we score good highest'.
"la fu ja ju" means "India score the highest"
and "ju uo na fu" means "highest of the country".

Then what is the code of "great" in this code language ?

QUESTION ID:16

If "A@B" means A is the mother of B

"A#B" means A is the father of B
"A₹B" means A is the son of B

How is X related to Z from the given equation?
X ₹ Y ₹ Z

QUESTION ID:17

Global Hunger Index is released by which of the following organizations ?

QUESTION ID:18

Seven dance students- T, U, V, W, X, Y and Z- are to give a performance, and the judges have to decide the sequence in which they will perform. Each student will perform exactly one item, a solo ballet. In deciding the order of performance, the instructor must observe the following restrictions:

1. X cannot perform first or second.
2. W cannot perform until X has performed.
3. Neither T nor Y can perform seventh.
4. Either Y or Z must perform immediately after W.
5. V must perform either immediately after or immediately before U.

If U performs third, what is the latest position in which Y can perform?

QUESTION ID:19

A country has seven major cities - A, B, C, D, E, F and G. Three flights labeled X, Y and Z are available to connect the cities following the rules:

Flight X has its ends at A and C, and passes through B only.
Flight Y has its ends at B and C, and passes through D only.
Flight Z has its ends at E and G. and passes through F only,
Directly connected cities are those cities between which there is no other city to land any flight.

Which of the following city is directly connected to the most other cities?

QUESTION ID:20

In how many different ways can the letters of the word AUCTION be arranged in such a way that the vowels always come together?

QUESTION ID:21

The surface area of a cube is 1734 s.q. cm. Then volume of cube is...

QUESTION ID:22

A small organ at the base of the brain that produces substances that affect growth and sexual development (hormones) is called:   (DROP)

QUESTION ID:23

QUESTION ID:24

How much time will it take for an amount of ₹ 4.5% to yield 81 of interest at 4.5% per annum of simple interest ?  (DROP)

QUESTION ID:25

The average of 7 consecutive numbers is 20. Then sum of smallest and greatest number is

QUESTION ID:26

During Translation termination, after the release of RFI, RF3 is also released by hydrolyzing its GTP. ____________ binds at A-site and then __________ binds at A-site which helps in translocation and helps in removal of E-site and P-site tRNA.

QUESTION ID:27

QUESTION ID:28

On the basis of the following hydropathy plots for three proteins (A-C) predict which would be membrane proteins?

QUESTION ID:29

Starting with glucose labelled in either position 1, 2 or 3 with 14C, which labelled molecule will be the first to lose the radioactive carbon as 14CO2 if the glucose is used exclusively for the glycolytic and TCA cycles.

QUESTION ID:30

Which of the following characteristics of proof-reading are essential to maintain fidelity in DNA replication?

QUESTION ID:31

Which one of the following correctly pairs an amino acid with a valid chemical characteristic?

QUESTION ID:32

Calculate the pH of a 2.0 L solution containing 10 ml of 5M acetic acid and 10 ml of 1 M sodium acetate (pk, of acetic acid = 4.76)?

QUESTION ID:33

Porin, a protein from the outer membranes of bacteria such as E.coli and Rhodobactercapsulatus represents a class of membrane proteins with a completely different type of structure. Structures of this type are built from (A) __________  and contain essentially no (B) __________, here A and B are, respectively:

QUESTION ID:34

Immunosuppressants such as prevents transplanted organs from being rejected in recipients.

QUESTION ID:35

If you have to find out whether a given protein is bound to a given gene in chromatin, which technique would you prefer using:

QUESTION ID:36

The hexose monophosphate shunt and the Entner-Douderoff pathway are alternative mechanisms for:

QUESTION ID:37

Which among the following is not required for the prokaryotic expression vector?

QUESTION ID:38

Microtubules mostly are made from:

QUESTION ID:39

What is the 'key' regulatory component of an 'Operon' model of regulation of gene expression in prokaryotes?

QUESTION ID:40

Which of the following proteins do not represent Quaternary structure?

QUESTION ID:41

If H is enthalpy, and T is temperature, the relationship between Entropy (S) and Gibbs energy (G) change can be expressed as:

QUESTION ID:42

At normal temperature and pressure one mole of a gas occupies a volume of:

QUESTION ID:43

Kcat is measured under:

QUESTION ID:44

Peptide bond is a:

QUESTION ID:45

Which of the following is the storage form of a lipid?

QUESTION ID:46

During mating between a Hfr strain and a F- recipient cell:

QUESTION ID:47

Identify the most simplest nutritional category of microorganisms:

QUESTION ID:48

The recommended percentage of dietary fat per day is:

QUESTION ID:49

The counterpart(s) of DNA polymerase III in eukaryotes is/are:

QUESTION ID:50

Why do erythrocytes swell and burst when placed in water?

QUESTION ID:51

Serum albumins and globulins can be separated by the method of:

QUESTION ID:52

SH2 domains specifically bind to:

QUESTION ID:53

Which of the following protein is the component of nucleoprotein?

QUESTION ID:54

Which ratio is constant for DNA?

QUESTION ID:55

Which of the following molecules binds strongly to avidin?

QUESTION ID:56

Tay-Sachs disease in the result of a genetic defeat in the metabolism of:

QUESTION ID:57

Which vitamin is derived from cholesterol?

QUESTION ID:58

Starch and glycogen are both polymers of:

QUESTION ID:59

Ascorbic acid deficiency is not associated with

QUESTION ID:60

Which of the following co-enzymes are not associated with pyruvate dehydrogenase complex?

QUESTION ID:61

Which of the following enzymes are not regulated by phosphorylation and dephosphorylation?

QUESTION ID:62

Inheritance from father to son is not possible in which of the following genetic conditions?

QUESTION ID:63

Which of the following hormones will not mediate their effect via G protein linked receptor pathway?

QUESTION ID:64

Tyrosine is not a precursor for which of the following molecules:

QUESTION ID:65

Which of the following is not true about conjugated bilirubin?

QUESTION ID:66

Which of the following is not a mettaloenzyme?

QUESTION ID:67

Formation of mature insulin includes all of the following except:

QUESTION ID:68

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: ATP binding is essential for the muscle relaxation event in the muscle function.
Reason R: The process is driven by cross-bridges which extend from the myosin filaments and cyclically interact with the actin filaments as ATP is hydrolyzed.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:69

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: Transcription and translation in prokaryotes is synchronous.
Reason R: Both are coupled processes occurring in the cytoplasm.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:70

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: The salting-out technique is one of the most commonly used methods for protein purification from a solution.
Reason R: At low salt concentration, protein solubility usually decreases and leading to precipitation.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:71

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: The DNA molecule is antiparallel and double helical structure.
Reason R: The backbone outside the double helix is made up of phosphate and sugar.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:72

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: IgG antibodies provides the passive immunity and protect the fetus.
Reason R: It crosses the placenta.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:73

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: Protein synthesis is a central function in cellular physiology and is the primary target of many naturally occurring antibiotics and toxins. Tetracyclines are a class of broad-spectrum antibiotics used in the management and treatment of a variety of infectious diseases by inhibiting translational machinery in bacteria.
Reason R: Tetracyclines inhibit protein synthesis in bacteria by blocking the A site on the ribosome, preventing the binding of aminoacyl- tRNAs.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:74

Given below are two statements: One is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: Vesicular transport is the predominant mechanism for exchange of proteins and lipids between membrane-bound organelles in eukaryotic cells. Golgi-derived vesicles are involved in several vesicular transport steps, including bidirectional transport within the Golgi and recycling to the ER. A protein X is a type II transmembrane protein (N-terminus in the cytosol) localized to the Golgi. If you add a KDEL sequence to its N-terminus, the mutant protein will localize in the Golgi.
Reason R: ER luminal proteins, especially those present at high concentrations, can be passively incorporated into COPII vesicles and transported to the Nucleus. Many such proteins bear a C-terminal KDEL (Lys-Asp-Glu-Leu) sequence that allows them to be retrieved. The KDEL receptor, located mainly in the nuclear network, binds proteins bearing the KDEL sorting signal and returns them to the ER. This retrieval system prevents depletion of ER luminal proteins such as those needed for proper folding of newly made secretory proteins.

In the light of the above statements, choose the most appropriate answer from the options given below:

QUESTION ID:75

What is the correct set of enzymes involved in base excision repair?

QUESTION ID:76

The genomes of viruses, prokaryotes and eukaryotes could be:

QUESTION ID:77

Given below are two statements:

Statement I: The a helix, ẞ strand and sheet, and ẞ turn are the most prevalent elements of protein secondary structure. Secondary structures are stabilized by hydrogen bonds between atoms of the peptide backbone.
Statement II: Protein tertiary structure results from hydrophobic interactions between nonpolar side groups and from hydrogen bonds and ionic interactions involving polar side groups and the polypeptide backbone. These interactions stabilize the folding of the protein. including its secondary structural elements, into an overall three-dimensional arrangement.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:78

Given below are two statements:

Statement I: Monoclonal antibodies, which bind one epitope of an antigen, can be secreted by cultured cells called hybridomas.
Statement II: These hybrid cells are made by fusing helper T-lymphocytes with immortal myeloma cells and then identifying those clones that produce the desired antibody.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:79

Given below are two statements:

Statement I: Immunofluorescence microscopy makes use of antibodies to localize specific components in fixed and permeabilized cells. Direct immunofluorescence microscopy uses an unlabeled secondary antibody, followed by a fluorescently labeled primary antibody that recognizes the secondary one and allows it to be localized.
Statement II: Fluorescence resonance energy transfer (FRET) is a technique in which light energy is transferred from one fluorescent protein to another when the proteins are very close, thereby revealing when two molecules are close in the cell.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:80

Given below are two statements:

Statement I: Nucleoid is not present in animal cells.
Statement II: The nucleoid is a chromatin-dense area within the cytoplasm and contains the bacterial DNA.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:81

Given below are two statements:

Statement I: cGMP is involved in the perception of light.
Statement II: Cyclic GMP-gated channels in the outer segment membrane are responsible for the light-included changes in the electrical activity of photoreceptors.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:82

Given below are two statements:

Statement I: Among the two nucleic acids, DNA and RNA found in living cells, DNA is considerably more stable than RNA.
Statement II: Double stranded state of DNA and single stranded state of RNA contributes to this status.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:83

Given below are two statements:

Statement I: Polymerase chain reaction (PCR) and Real-time polymerase chain reaction (RT-PCR) are techniques.
Statement II: They have invented for in vitro amplification of DNA as well as RNA.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:84

Given below are two statements:

Statement I: Diethylaminoethyl Cellulose (DEAE-C) is typically used in ion-exchange chromatography for the separation and purification of proteins.
Statement II: DEAE-Cellulose is cationic exchanger.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:85

Given below are two statements:

Statement I: The Gibbs energy change of a process can be determined by performing measurements under equilibrium conditions.
Statement II: Gibbs energy change at equilibrium is zero.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:86

Given below are two statements:

Statement I: In Non-competitive inhibitor, Km remains unaltered while Vmax
Statement II: Km increases and Vmax remains unchanged. is reduced.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:87

Given below are two statements:

Statement I: IgM antibody is pentamer
Statement II: It has five combining site

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:88

Given below are two statements:

Statement I: Free living cells usually incorporate free DNA molecules in its genome.
Statement II: This process is known as transformation.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:89

Match List I with List II 

List IList II
A. Ion-exchange chromatographyI. Specific binding interaction between an immobilized ligand
B. DialysisII. Net surface charge
C. Affinity chromatographyIII. Differential Partitioning
D. Thin layer chromatographyIV. Removing waste products
Choose the correct answer from the options given below:

QUESTION ID:90

Match List I with List II 

List IList II
A. HydrolaseI. Acetyl-CoA synthetase
B. OxidoreductaseII. Pyruvate kinase
C. TransferaseIII. Cytochrome oxidase
D. LigaseIV. Lipase

Choose the correct answer from the options given below:

QUESTION ID:91

Match List I with List II 

List IList II
A. Lag PhaseI. Exponential phase
B. Log PhaseII. Depletion of an essential nutrient
C. Stationary phaseIII. Adaptation to growth condition
D. Death phaseIV. Decline phase

Choose the correct answer from the options given below:

QUESTION ID:92

Match List I with List II 

List IList II
A. MycobacteriumI. AIDS
B. Retro VirusII. Tuberculosis and leprosy
C. PlasmodiumIII. Diarrheal illness
D. Vibrio choleraIV. Malarial fever

Choose the correct answer from the options given below:

QUESTION ID:93

Match List I with List II 

List IList II
A. GlycolysisI. Isocitrate dehydrogenase
B. TCA cycleII. Pyruvate kinase
C. Urea cycleIII. Phosphoribulokinase
D. Calvin cycleIV. Argininosuccinate synthetase

Choose the correct answer from the options given below:

QUESTION ID:94

Match List I with List II

List IList II
A. B CellsI. Tissue macrophages
B. T cellsII. Tumor cells
C. NK cellsIII. Bursa of fibricius
D. MonocytesIV. Thymus
Choose the correct answer from the options given below:

QUESTION ID:95

Match List I with List II

List IList II
A. ABC TransporterI. Na+K+ATPase
B. P type ATPaseII. Glucose transporter
C. F type ATPaseIII. Cystic Fibrosis
D. Passive transporterIV. ATP synthase
Choose the correct answer from the options given below:

QUESTION ID:96

Match List I with List II

List IList II
A. DNA Polymerase II. Highest polymerization rate (250-1000 nt/sec)
B. DNA Polymerase IIII. 5'-3' Exonuclease activity
C. DNA Polymerase IIIIII. Least molecular weight (80000 Da)
D. DNA Polymerase IVIV. DNA repair, translesion synthesis

Choose the correct answer from the options given below:

QUESTION ID:97

Match List I with List II

List IList II
A. 3' 5' cAMP (cyclic AMP)I. Nitroglycerin
B. CalciumII. Phorbol esters
C. 1, 2 DAG (Diacyl glycerol)III. Forskolin
D. 3' 5' cGMP (cyclic GMP)IV. Calmodulin
Choose the correct answer from the options given below:

QUESTION ID:98

Match List I with List II

List I (Ions)List II Cell (mM)
A. K+I. 145-155
B. Na+II. 0.001 – 0.003
C. Cl-III. 3.8 – 4.0
D. Ca2+IV. 10 – 12
Choose the correct answer from the options given below:

QUESTION ID:99

Match List I with List II

List IList II
A. RNA polymerase II. mRNA, siRNA, miRNA
B. RNA polymerase IIII. Pre rRNA
C. RNA polymerase IIIIII. tRNA, snRNA
D. DNA polymerase γIV. Mitochondrial DNA replication and repair
Choose the correct answer from the options given below:

QUESTION ID:100

Match List I with List II

List I (G α class)List II (Receptor examples)
A. G α sI. Rhodopsin in rod cells
B. G α iII. β - Adrenergic (epinephrine) Receptor; receptors for glucagon, Serotonin, vasopressin
C. G α qIII. α 2-Adrenergic receptor Muscarinic acetylcholine receptor
D. G α tIV. α 1-Adrenergic receptor

Choose the correct answer from the options given below: