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QUESTION ID:1
Primary changes in Acid Base disorders are :
A. Metabolic acidosis decreased plasma bicarbonate
B. Metabolic alkaloses decreased plasma bicarbonate
C. Respiratory alkalosis decreased pco2
D. Respiratory acidosis decreased pco2
Choose the correct answer from the options given below :
QUESTION ID:2
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : A covlent single bonds in biological molecules have energies similar to the energy of the C-C bond in ethane.
Reason (R) : It is because less electrons are shared between atoms in double bonds they require more energy to break than single bonds.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:3
A solution is called hypertonic when :
QUESTION ID:4
List - I shows various isotopes and List - II indicates their half-lives. Match List - I with List - II.
| List - I | List - II |
| A. 3H | I. 60 days |
| B. 14C | II. 14.5 days |
| C. 32P | III. 5700 years |
| D. 125I | IV. 12.2 years |
QUESTION ID:5
Based on the position of Centromere Chromosome can be divided into 4 types :
A. Meta centric : Centromere in the middle
B. Submetacentric : Centromere at the end
C. Telocentric : Terminal Centromere
D. Acrocentric : Centromere is close to middle
Choose the correct answer from the options given below :
QUESTION ID:6
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Neurons are the functional cells in brain. Glial cells are the supporting cells of the brain.
Reason (R) : Astroglia are starshaped neuronal cells.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:7
Which of the following are the correct components of PCR reation ?
A. Taq Polymerase
B. Buffer (5X)
C. Primers (F and R)
D. NTPs
E. H2O
Choose the correct answer from the options given below :
QUESTION ID:8
List the proteins detection techniques in increasing order of sensitivity :
A. Bradford
B. Biuret
C. Lowry
Choose the correct answer from the options given below :
QUESTION ID:9
Match List - I with List - II.
| List - I | List - II |
| A. ELISA | I. Visualization of cells |
| B. RIA | II. Proteins identification |
| C. Centrifugation | III. Hormone detection |
| D. Microscopy | IV. Isolation of organelles |
QUESTION ID:10
Match List - I with List - II.
| List - I | List - II |
| A. SDS-PAGE | I. DNA |
| B. Agarose gel electrophoresies | II. Liquid chromatography |
| C. Native Page | III. Non-denatured proteins |
| D. HPLC | IV. proteins |
QUESTION ID:11
How many cycles of β-oxidation are required for the complete oxidation of activated Oleic acid, 18 : 1 (Δ9)?
QUESTION ID:12
Which one of the test, is not given by proteins ?
QUESTION ID:13
Which one of the following is not a test for sugar ?
QUESTION ID:14
NAD+ dependent enzyme are/is :
A. Glyceraldehyde 3-phosphate dehydrogenase
B. Lactate dehydrogenase
C. Malic enzyme
D. HMG CoA reductase
Choose the correct answer from the options given below :
QUESTION ID:15
Conversion of L-Tyrosine to Epinephrine includes :
A. L-Tyrosine → DOPA
B. Norepinephrine → Dopamine
C. DOPA → Dopamine
D. Epinephrine → Norepinephrine
Choose the correct answer from the options given below :
QUESTION ID:16
Outlines of cholesterol biosynthesis includes :
A. 2 Acetyl CoA → Acetoacetyl CoA
B. Mevalonate → HMG CoA
C. Acetoacetyl CoA → HMG CoA
D. Acetoacetyl CoA → 2 Acetyl CoA
E. HMG CoA → Mevalonate
Choose the correct answer from the options given below :
QUESTION ID:17
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : In a zinc finger about-30 amino acids form an elongated loop held together at the base by a single Zn2+ ion which is coordinated to four residues (with Cys and/ or His)
Reason (R) : The Zn does not itself interact with DNA, rather the coordination of Zn with amino acid residues stabilizes the small structural motif.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:18
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Protein synthesis is a central function in cellular physiology and is the primary target of many naturally occurring antibiotics and toxins. Tetracyclines are class broad spectrum antibiotic used in the management and treatment of infectious disease by inhibiting translational machines in bacteria.
Reason (R) : Tetracyclines inhibit protein synthesis in bacteria by blocking the A site on the ribosome, preventing the binding of aminoacyl tRNA.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:19
What are the different forms of Alanine ?
QUESTION ID:20
Why the absorption of UV light by double stranded DNA increases (hyperchromic effect) when the DNA is denatured ?
QUESTION ID:21
Match List - I with List - II.
| List - I | List - II |
| A. Carbohydrate | I. 9.4 cal/g |
| B. Fat | II. 4.1 cal/g |
| C. Proteins | III. 7.1 cal/g |
| D. Alcohol | IV. 5.4 cal/g |
QUESTION ID:22
Match List - I with List - II.
| List - I | List - II |
| A. Iron | I. Cardiomyopathy |
| B. Copper | II. Pernicious Anemia |
| C. Cobalt | III. Menke's disease |
| D. Selenium | IV. Microcytic anemia |
QUESTION ID:23
Different forms of Vitamin A are :
A. Retinal (Vitamin A aldehyde)
B. Retinyl Palmitate (Vitamin A acid)
C. Retinol (Vitamin A alcohol)
D. Retinyl ester (Vitamin A ester)
E. β-carotene (provitamin A)
Choose the correct answer from the options given below :
QUESTION ID:24
To find out if a person is diabetic or not, what will be the easiest and the best test he/she should go for :
QUESTION ID:25
A person is eating polished rice throughout his life, deficiency of which vitamins he/she is likely to have ?
QUESTION ID:26
The correct order of enzymes involved in the synthesis of pyrimidine nucleotide is :
A. Aspartate transcarbomylase
B. Dihydroorotase
C. Carbamoyl phosphate synthetase II
D. Dihydroorotate dehydrogenase
E. OMP decarboxylase
Choose the correct answer from the options given below :
QUESTION ID:27
Arrange the enzymes of glycolysis in correct order ?
A. Hexokinase
B. Glyceraldehyde-3-phosphate dehydrogenase
C. Aldolase
D. Phosphohexose isomerase
E. Phosphofructokinase-1
Choose the correct answer from the options given below :
QUESTION ID:28
Match List - I with List - II.
| List - I | List - II |
| A. Citric Acid Cycle | I. Phosphofructokinase |
| B. Glycolysis | II. Citrate synthase |
| C. Pyruvate Oxidation | III. Glycogen synthase |
| D. Glycogenolysis | IV. Pyruvate dehydrogenase |
QUESTION ID:29
Match List - I with List - II.
| List - I | List - II |
| A. Hyper ammonia type I | I. Arginase |
| B. Hyper ammonia type II | II. Arginosuccinate synthase |
| C. Citrullinemia | III. Ornithine transcarbomylase |
| D. Hyperargininemia | IV. Carbamoyl phosphate synthase |
QUESTION ID:30
Unique features of metabolism of principal organs is/are :
A. Heart : Transport of O2
B. Adipose tissue : Rapid movement
C. Kidney : Excretion and gluconeogenesis
D. Brain : Coordination of nervous system
Choose the correct answer from the options given below :
QUESTION ID:31
Inherited disorders of purine metabolism is/are :
A. Lesch-Nyhan syndrome due to Adenosine deaminase
B. Xanthinuria due to xanthine oxidase
C. Renal lithiasis due to adenosine deaminase
D. Gout due to PRPP synthetase
Choose the correct answer from the options given below :
QUESTION ID:32
Steps in the metabolism of Tyrosine.
A. Phenylalanine Tyrosine
B. Homogentisate Fumarrate
C. Tyrosine hydroxyphenyl pyruvate
D. Phenylalanine Homogentisate
Choose the correct answer from the options given below :
QUESTION ID:33
The DNA-binding domain of steroid receptors is located :
QUESTION ID:34
Correct sequence of steps of citric Acid Cycle :
A. Succinyl CoA
B. Acetyl CoA
C. Citrate
D. α-ketoglutarate
E. Malate
Choose the correct answer from the options given below :
QUESTION ID:35
Correct sequence of electron transport chain reactions is :
A. Substrate → NAD+
B. NAD+ → FMN
C. CoQ → Cyt b
D. FMN → CoQ
E. Cyt a → Cyta3
Choose the correct answer from the options given below :
QUESTION ID:36
Match List - I with List - II.
| List - I | List - II |
| A. Epidermal growth factory (EGF) | I. Monocyte |
| B. Platelet derived growth factor (PDGF) | II. Salivary gland, fibroblast |
| C. Transforming growth factor (TGF-α) | III. Platelet |
| D. Tumor necrosis factor (TNF-α) | IV. Epithelial cells |
QUESTION ID:37
Some of the Bile acids are :
A. Deoxycholic acid
B. Oxalic acid
C. Taurocholic acid
D. Acetoacetic acid
Choose the correct answer from the options given below :
QUESTION ID:38
Identify the steps in the formation of vitamin D3 :
A. Vitamin D4 ⟶ 25-Hydroxycholecalciferol
B. Provitamin D3 ⟶ Vitamin D3
C. 7-Dehydrocholestrol Provitamin D
D. 25-Hydroxycholecalciferol ⟶ Vitamin D3
Choose the correct answer from the options given below :
QUESTION ID:39
An axonal process 2 meter long is originating in spinal cord and terminating in the muscles of toes. If the average velocity of a vesicle is 1 μm/s how long does it take a vesicle to move from a cell body in the spinal cord to the axonal tip in the toes ?
QUESTION ID:40
Match List - I with List - II.
| List - I | List - II |
| A. Albumin | I. Damage to kidneys or urinary trace |
| B. Hemoglobin | II. Kidney damage |
| C. Glucose | III. Diabetes mellitus |
| D. Bile pigments | IV. Obstructive jundice |
QUESTION ID:41
Match List - I with List - II.
| List - I | List - II |
| A. 6-mercaptopurine | I. Monoclonal antibody |
| B. Mitomycin | II. Platinum compound |
| C. Cisplatin | III. Antibiotic |
| D. Tmatinib | IV. Purine analogue |
QUESTION ID:42
Match List - I with List - II.
| List - I | List - II |
| A. Biuret reactions | I. α-Amino acid |
| B. Ninhydrin test | II. Two peptide linkage |
| C. Millons reaction | III. Guanidino group |
| D. Sakaguchi reaction | IV. Phenolic group (Tyr) |
QUESTION ID:43
Blood glucose/glycation value of a non-diabetic person :
A. 140-199 mg/dL
B. 5.5 HbA1c
C. 75-100 mg/dL
D. 7.0 HbA1c
Choose the correct answer from the options given below :
QUESTION ID:44
Genetic Disorders in human is/are :
A. Down's syndrome - Trisomy at chromosome 21
B. Parkinson's disease - Tyrosine hydroxylase
C. Diabetes millitus
D. Phenylketonuria - Phenylalanine hydroxylase
Choose the correct answer from the options given below :
QUESTION ID:45
Identify the proteins with correct function :
A. Cytochrome C - Electron Transport chain
B. Hemoglobin - Storage of O2 in muscle
C. Catalase - Degradation of hydrogen peroxides
D. Myoglobin - Transport of O2 in blood
Choose the correct answer from the options given below :
QUESTION ID:46
Enzymes used in recombinant research are :
A. Terminal Transferases
B. Pyruvate kinase
C. Reverse Transcriptase
D. Hexokinase
Choose the correct answer from the options given below :
QUESTION ID:47
The complement system helps the body immunity in following 4 ways. Its correct sequences is :
A. Inflammatory reaction
B. Opsonization
C. Complement fixation
D. Clearance of antigen-antibody complexes
Choose the correct answer from the options given below :
QUESTION ID:48
Which immune system fails to discriminate between self and non-self ?
A. Insulin - dependent diabetes (β-cell antibodies)
B. Asthama (antibodies against lung cells)
C. Myasthenia gravis (acetyl choline receptor autoantibodies)
D. Hepatitis (antibody against hepatic cells)
E. Rheumatoid arthritis (antibodies against joint protein)
Choose the correct answer from the options given below :
QUESTION ID:49
Enzymes are classified on the basis of reaction they catalyze. Which of the following are correct combinations ?
A. Oxidoreductase : Oxidation-reduction reaction
B. Transferases : Transfer of group
C. Hydrolases : Catalyze hydrolysis
D. Lyases : Addition of group
E. Ligases : Catalyze inter-conversion of group
Choose the correct answer from the options given below :
QUESTION ID:50
Recent studies using GFP fusion proteins have allowed study of protein dynamics in living cells. Initially, GFP was derived and cloned from :
QUESTION ID:51
Match List - I with List - II and choose the correct matches :
| List - I | List - II |
| A. SnRNA | I. Serves as precursor for mRNA |
| B. LncRNA | II. Inhibits gene expression |
| C. miRNA | III. Regulates mRNA synthesis |
| D. hnRNA | IV. Involved in mRNA processing |
QUESTION ID:52
Choose correct options regarding enzyme with their respective substrates :
A. Monoamine oxidase : Catecholamines
B. HMG CoA reductase : Hypoxanthine xanthine
C. Acetyl choline esterase : Acetyl choline
D. Dihydropteroate synthase : Para-amino benzoic acid (PABA)
E. Vitamin K epoxy reductase : Amphetamine
Choose the correct answer from the options given below :
QUESTION ID:53
Which statement is correct about the isoenzymes of LDH ?
QUESTION ID:54
What will happen to a crude extract of urease when it is purified by gel filtration ?
QUESTION ID:55
What are prosthetic groups ?
QUESTION ID:56
A store-bought corn (several days after picking) is not very sweet due to the fact that :
QUESTION ID:57
What are the correct steps in the synthesis of light chain of immunoglobins ?
A. mRNA
B. Rearranged DNA
C. Original DNA
D. Primary transcript
E. Protein (light chain of Ig)
Choose the correct answer from the options given below :
QUESTION ID:58
What is the correct sequence of polymerase Chain Reactions ?
A. Annealing
B. Extension
C. Final extension
D. Heat-denaturation
E. Storage (4°C)
Choose the correct answer from the options given below :
QUESTION ID:59
List - I shows various cloning vectors and List - II indicates their DNA insert sizes. Match List - I with List - II correctly.
| List - I | List - II |
| A. Plasmid PBR322 | I. 0.5 - 3.0 Mb |
| B. Cosmid | II. 0.01 - 10 Kb |
| C. BAC, P1 | III. 35 - 50 Kb |
| D. YAC | IV. 50 - 250 Kb |
QUESTION ID:60
Bacillus thuringiensis (BT) produces proteins that kill certain insects and save crops :
A. Bt toxin exist in inactive form (prototoxin) in bacteria
B. Acidic pH of the insect gut activate toxin
C. Bt toxin (protein) is present in beetles
D. Due to the alkaline pH in the insect's gut it is converted into active toxin to kill the insects
Choose the correct answer from the options given below :
QUESTION ID:61
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : When an individual amino acid is part of a peptide or protein it is called amino acid residue.
Reason (R) : When an amino acid becomes part of a protein or peptide through peptide bond it loses a molecule of water and is called amino acid residue.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:62
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Penicillin is an antibiotic that is used for killing bacteria.
Reason (R) : Antibiotic penicillin kills bacteria by inhibiting bacterial cell wall synthesis.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:63
Which of the following enzymes under appropriate conditions produce single-stranded nicks in DNA ?
QUESTION ID:64
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Rifampicin is used to treat various bacterial infections particularly tuberculosis.
Reason (R) : It acts by disrupting the bacterial cell-wall, nuclear membrane and mitochondria.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:65
Identify the correct set(s) of essential amino acids :
A. Alanine, Lysine
B. Lysine, Methionine
C. Threonine, Serine
D. Methionine, Threonine
Choose the correct answer from the options given below :
QUESTION ID:66
Match List - I with List - II.
| List - I | List - II |
| A. Macrophages | I. Secrete cytokines (interleukins) |
| B. B-lymphocytes (B-cells) | II. Gaseous-exchange |
| C. Helper T-cells | III. Ingest large particles and cells by phagocytosis |
| D. Reticulocytes | IV. Produce and secrete antibodies |
QUESTION ID:67
Arrange the following phases of cell cycle in order of occurrence :
A. S phase
B. M phase
C. G1 phase
D. G2 phase
Choose the correct answer from the options given below :
QUESTION ID:68
Arrange the following stages of spermatogenesis in proper sequence of sperm development :
A. Spermatids
B. Spermatocytes
C. Spermatogonia
D. Spermatozoa
Choose the correct answer from the options given below :
QUESTION ID:69
Arrange the following stages in sequence shown for human embryogenesis :
A. Zygote
B. 8-cell stage
C. Gastrula
D. Blastula
E. Morula Choose the correct answer from the options given below :
QUESTION ID:70
Mammalian cell division produces progeny cells by transversing different phases of mitosis. Arrange them in order of occurrance.
A. Prophase
B. Telophase
C. Interphase
D. Anaphase
E. Metaphase
Choose the correct answer from the options given below :
QUESTION ID:71
Which of the following organs has both exocrine and endocrine functions ?
QUESTION ID:72
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Some cell signalling receptor are at the cell surface with transmembrane domains that help them embed in the plasma membrane.
Reason (R) : They are localized at the cell surface as their activating ligands cannot enter the cell interior.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:73
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Intracellular receptors functioning as transcription factors are activated by functional ligands.
Reason (R) : They are activated in the interior of the cell (unlike extracellular receptors) because their functional ligands are lipophilic in nature.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:74
Given below are two statements : one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Tropic hormones act on other endocrine glands to stimulate release of their hormone and transmit signalling through cell surface receptors.
Reason (R) : This action is attributed to their lipophilic nature.
In the light of the above statements, choose the most appropriate answer from the options given below :
QUESTION ID:75
Which of the following is an active form of thyroid hormone that acts through a nuclear receptor to stimulate energy-yielding metabolism by increasing the expression of genes encoding key catabolic enzymes ?
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