Previous Year Questions (PYQ) | 2017-April | DBT-JRF BET

QUESTION ID:1

Assessment of the extent of DNA double strand breaks in cultured human cells, following exposure to ionizing radiation, can be done by quantitation of :

acetylated histones H3 and H4

methylated histones H3 and H4

ubiquitylated histone H2A.X

phosphorylated histone H2A.X

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QUESTION ID:2

There are reports of more than 100 mutations at different sites of Factor IX that manifests Haemophilia B. This is an example of:

clinical heterogeneity

allelic heterogeneity

protein heterogeneity

locus heterogeneity

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QUESTION ID:3

Specificity factor which activates ubiquitin ligase activity of APC/C during separation of sister chromatids is:

CDC10

CDC20

CDH1

CDC45A

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QUESTION ID:4

In a diploid organism, loss of function mutations produce dominant phenotypes when there is:

pleiotropy

epistasis

multiple allelism

haploinsufficiency

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QUESTION ID:5

In Mendel‟s dihybrid cross experiment, if the two selected traits were on the same chromosome (linked) and assuming that there is no recombination, what would be the

expected genotypic ratio in the F2 generation?

1:2:1

9:3:3:1

1:3

1:1

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QUESTION ID:6

Huntington disease is caused by:

Expanded dinucleotide repeats sequence in coding region

Expanded trinucleotide repeats in non-coding region

Expanded trinucleotide sequence in coding sequence

Expanded dinucleotide sequence in non-coding sequence

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QUESTION ID:7

The following pedigree shows the inheritance of a very rare human disease. What is the most likely mode of inheritance for the disease trait and what is the probability that the second child of III-2 and III-3 will be a son and will also have the disease?

Sex-linked recessive; 0.5

Autosomal recessive; 0.25

Autosomal dominant: 0.75

Autosomal dominant; 0.25

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QUESTION ID:8

Microscopic evaluation of a post-mortem brain exhibits hyperchromatic areas when stained with glial fibrillary acidic protein (GFAP). This suggests activation of:

astrocytes

oligodendrocytes

Microglia

neurons

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QUESTION ID:9

Parasite numbers in the blood of a patient with Trypanosoma brucci (Sleeping sickness) shows the following pattern:

Parasites isolated from population 1 and 2 were found to be antigenecially noncross reactive. The parasite distribution seen may be due to:

Change in gene expression

Loss of antigenic epitopes

Post-translational modification of antigen

Antigenic switching

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