Menu

Previous Year Questions

TLS Online TPP Program

QUESTION ID:1

Match the type of Organism in Group A with appropriate phenotype/property from Group B.
Group A                                                   Group B
P) Pseudomoans aeruginosa             i) Sulfur oxidizing organism
Q) Staphylococcus aureus                ii) Elemental N2 fixation
R) Thiobacillus ferroxidance            iii) Biofilm formation
S) Bradyrhizobium                            iv) Quorum sensing

QUESTION ID:2

Which one of the following reactions is performed by Cytochrome-P450 to detoxify the xenobiotics?

QUESTION ID:3

Which one of the following is NOT true regarding Zika virus?

QUESTION ID:4

The vaccine currently used in India’s Pulse polio campaign is

QUESTION ID:5

Which one of the following enzymes helps in the survival of Helicobacter pylori in the stomach?

QUESTION ID:6

Which one of the following is INCORRECT about Streptokinase?

QUESTION ID:7

The utility of positron emission tomography to diagnose tumors is based on

QUESTION ID:8

Which one of the following imaging techniques is non-invasive?

QUESTION ID:9

Amphotericin B is clinically used against which one of the following pathogens?

QUESTION ID:10

The therapeutic index (TI) indicates the relative margin of safety of a drug and it is deduced from the values of mean lethal dose (LD50) and median effective dose (ED50). Which of the following represents TI of a drug?

QUESTION ID:11

Which one of the following is a frequently used radio-opaque dye?

QUESTION ID:12

The name of the blood vessel marked [?] in the figure below is


QUESTION ID:13

Which one of the following is a reason for administering general anesthesia to experimental animals?

QUESTION ID:14

During the pathogenesis of rabies, the replication of virus first starts in the

QUESTION ID:15

Callipyge gene mutation in sheep leads to increased muscle growth. The gene presents a typical case of Polar over-dominance. Which of the four genotypes given below shows increased muscle growth? (N= wild type allele, C= mutant allele for callipyge)

QUESTION ID:16

The technique used in animal biotechnology for the rapid multiplication and production of animals with a desirable genotype is:

QUESTION ID:17

A primary culture of neurons isolated from the mouse brain responded positively when exposed to a chemical for a few seconds, but the neurons were less responsive and eventually stopped responding when exposed to the same chemical for prolonged duration. However, if the culture was left for some time and washed, the neurons started responding to the same chemical at the same concentration as before. The reduced response was due to

QUESTION ID:18

If a neuron is tyrosine hydroxylase positive, it could be either:

QUESTION ID:19

Pain sensation is a subjective and conscious feeling. However, although the autonomic organs viz. brain, heart etc. do not get represented in the cerebral cortex, one feels pain in those parts as well. The reason is

QUESTION ID:20

Neurons are formed from precursor proneural cells due to

QUESTION ID:21

A neuron at resting state when treated with “X” showed transmembrane potential -50mV, while when treated with “Y” it showed -90mV. Given such a condition, which of the following statements would be most appropriate?

QUESTION ID:22

Route of entry for canine distemper virus is

QUESTION ID:23

In a population which is in Hardy-Weinberg equilibrium, the frequency of a recessive allele for a certain genetic trait is 0.40. What percentage of individuals would be expected to show the dominant trait in the next generation?

QUESTION ID:24

Color blindness in human is a sex-linked recessive trait. If two individuals with normal color vision have a color blind son, what will be the genotypes of the parents?

QUESTION ID:25

A human is phenotypically female, but her interphase somatic nuclei do not display the existence of Barr bodies. Which of the following conditions could explain the above feature?

QUESTION ID:26

For the pedigree depicted below, which mode(s) of inheritance CANNOT be possible?

QUESTION ID:27

C banding of human chromosomes specifically reveals

QUESTION ID:28

Which one of the following expressions is likely to retrieve more matches in a database search?

QUESTION ID:29

Which substitution matrices should you prefer to find distantly related orthologs through BLAST search?

QUESTION ID:30

Match the items in Group 1 with an appropriate description in Group 2
Group I                                      Group 2
P. UPGMA                         1. Protein sequence database
Q. CLUSTALW                  2. Phylogenetic Analysis
R. SWISS-PROT              3. 3-D structure visualization
S. RasMol                         4. Multiple sequence alignment

QUESTION ID:31

The rate of substitutions in a certain region of DNA of length 1000 bases is estimated as 10-9 per base per year. If two species diverged approximately 10 million years ago, the fraction of sites that differ between them should be approximately

QUESTION ID:32

When searching the Blocks and PRINTS databases, a match is judged significant if

QUESTION ID:33

Two species are found to share a cluster of 8 genes, but the genes are in different orders in the two species. The orders are represented by signed permutations as given below:
Species X 1,2,3,4,5,6,7,8
Species Y 1, 2,-5,-4,-3,8,6,7
The transformation between the two gene orders

QUESTION ID:34

As the E value of a BLAST search becomes smaller

QUESTION ID:35

In a genome with average GC-content 40%, the expected frequency of occurrence of the tetranucleotide AACG is

QUESTION ID:36

Consider that you have collected X-ray diffraction data on three different protein crystals, referred to as Protein A, B and C. Data set for crystal A has the best diffraction spot at 8A, crystal B at 5A and crystal C has the best diffraction at 3A. Which data set is likely to yield a higher resolution crystal structure?

QUESTION ID:37

In a protein crystallization experiment, you have identified an optimal protein concentration and precipitant concentration which yield crystals. Now if you are asked to grow crystals again with a protein solution that is four times more concentrated, how will you alter the precipitant concentration?

QUESTION ID:38

Which of the following statements is true for two different tripeptides consisting of either glycine or proline?

QUESTION ID:39

In a Fluorescence Resonance Energy Transfer (FRET) experiment, the donor is Cyan Fluorescent Protein (CFP) which has excitation and emission maxima at 435 and 485 nm, respectively. The acceptor in this experiment is Yellow Fluorescent Protein (YFP) that has excitation and emission maxima at 513 and 545 nm, respectively . Under the conditions, where a significant FRET is observed, what will happen to the FRET signal if the emission maxima of CFP is made to shift to 475nm.

QUESTION ID:40

Consider that the following polypeptides are being analyzed by Mass spectrometry (MS). These peptides are generated by proteolytic cleavage of a protein that is expressed in mammalian cells and it has undergone glycosylation, phosphorylation and acetylation. What will the expected positioning of the spectra corresponding to these peptides (smaller to larger)?

QUESTION ID:41

Assuming that the sequence of CDRs of an antibody are heavily enriched with Tyrosine and Serine, what is likely to be the driving force stabilizing its interaction with the antigen?

QUESTION ID:42

Hydrophobic amino acids are prevalent in transmembrane regions of membrane embedded proteins because

QUESTION ID:43

Bryostatin is an anticancer agent obtained from

QUESTION ID:44

Synthesis of White spot syndrome virus envelop takes place in

QUESTION ID:45

Primary etiology of Epizootic Ulcerative Syndrome is a Fungus Aphanomyces invadans. Its zoospores have the property to

QUESTION ID:46

Gonad Inhibiting Hormone (GIH) in crustaceans is synthesized in

QUESTION ID:47

The synthetic equivalent of neuro-pharmacologically active peptides obtained from the marine snail Conus magus is

QUESTION ID:48

Viral encephalopathy and retinopathy in fishes are caused by

QUESTION ID:49

A pigment isolated from marine red algae that finds application in flow cytometry is

QUESTION ID:50

Which of the following electron acceptor that is used by the bacteria is mainly responsible for marine corrosion?

QUESTION ID:51

Which one of the following bacterial species is responsible for the Scombroid fish poisoning?

QUESTION ID:52

The larval stage of Macrobrachium rosenbergii is referred to as

QUESTION ID:53

The group of marine algae which have urea cycle is

QUESTION ID:54

Which of the following algae is responsible for the red color of RED SEA?

QUESTION ID:55

An oligotrophic lake has

QUESTION ID:56

After sodium chloride, which one of the following compounds has the maximum concentration in sea water?

QUESTION ID:57

Which of the following is an example of an intellectual property right?