Menu

Previous Year Questions

TLS Online TPP Program

QUESTION ID:1

Variation in which types of repeat sequence commonly arise by replication slippage?

QUESTION ID:2

One form of congenital deafness in human is inherited as a recessive condition and controlled by two independent genes (A and B). In the pedigree depicted below, two deaf individuals have children with normal hearing ability. 

What would be the probable genotypes of the deaf parents? 

QUESTION ID:3

Genetic relatedness between mothers and daughters in haplodiploid organisms is

QUESTION ID:4

In a family, among the siblings, there is a heterozygous girl for haemophilia, a normal boy, a haemophilic girl and a haemophilic boy. Which of the following genotypes would be attributed to the parents?

QUESTION ID:5

Which among the following is a proper definition of a SMILES string ?

QUESTION ID:6

Which of the following is a correct statement regarding sensitivity and specificity of a search algorithm?

QUESTION ID:7

Which of the following statements is true for the BLAST algorithm for sequence comparison?

QUESTION ID:8

A mixture containing L-Aspartate, D-Aspartate and L-Lysine was set up for crystallization and produced a single crystal belonging to space group P2/m (Primitive cell with a 2-fold rotation axis and a mirror plane perpendicular to the rotation axis). Which of the following is the most likely composition of the crystal?

QUESTION ID:9

Which of the following statements best describe the significance of the Temperature factor (B-factor) column in a PDB file?

QUESTION ID:10

Peaks in 1H-NMR spectra are often split into multiplets due to spin-spin coupling with neighbouring protons. Surprisingly, peaks in 13C-NMR spectra appear much simpler with very little evidence of 13C-13C coupling. Which one of the following statements offers the best explanation for the above observation?

QUESTION ID:11

For any molecule with N atoms (N > 3), the minimum number of internal coordinates (bond lengths, bond angles and dihedral angles) sufficient to describe the structure of the  molecule is given by:

QUESTION ID:12

A scientist screening for monoclonal antibodies against a protein antigen isolates two antibodies, the first of which recognizes a conformational epitope in the form of an α- helix in the protein, and a second one that also recognizes a conformational epitope, but in the form of just one strand in a multi-stranded β-sheet. The scientist then synthesizes small peptides with the same sequences corresponding to the two epitopes and tests for binding with antibodies. Which of the following is the most likely outcome of her experiments?

QUESTION ID:13

Which of the following cases will most likely lead to sequence specific recognition of DNA by a protein?

QUESTION ID:14

Which of the following algorithms is most likely to be used as an optimizer for Docking calculations?

QUESTION ID:15

A certain chemical carcinogen causes a lethal chemical modification in DNA bases with a probability of 10-7. It was found that if cultured human cells are treated with this compound then approximately 1% of the amount added makes its way to the nucleus and attacks the chromosomes. What is the approximate probability of obtaining at least one base modification event per cell, if cultured human cells are treated with the compound at a concentration of 1mmol/cell.

QUESTION ID:16

When p and q are lengths of sequences, the computational complexity of the Smith- Waterman algorithm is

QUESTION ID:17

Which among the following is a measure of similarity between two chemical structures of small molecules?

QUESTION ID:18

A closed circular DNA molecule is treated with saturating concentrations of an intercalator followed by treatment with topoisomerase until it is completely relaxed. If the intercalator is now removed by dialysis, the DNA molecule will become

QUESTION ID:19

Which among the following amino acids has at least ONE asymmetric carbon atom in its side-chain?

QUESTION ID:20

A right handed α-helix made up of L-amino acids has φ,ψ angles of -60 and -40 degrees respectively. Which of the following will be the φ,ψ angles of a left handed α-helix made up of D-amino acids only?

QUESTION ID:21

The membrane permeability of Dimethyl urea is:

QUESTION ID:22

Which of the following statements is true with respect to the formation of disulfide bonds in a protein produced by eukaryotic cells?

QUESTION ID:23

Circular dichroic spectra of some proteins show a strong negative ellipticity band at 200 nm. Which of the following secondary structures is characterized by the presence of this band?

QUESTION ID:24

Water has a high dielectric constant of 80 in contrast with many non-polar solvents having very low dielectric constants. Due to this property the electrostatic interactions between various side-chains of amino acids in proteins after their transfer from nonpolar solvent to water would: