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Previous Year Questions

TLS Online TPP Program

QUESTION ID:1

5-Bromouracil induces mutations because it

QUESTION ID:2

A homeotic mutation is one which

QUESTION ID:3

Cystic fibrosis is a recessive condition that affects about 1 in 2,500 babies in the Caucasian population. The frequency of heterozygotes or carriers of cystic fibrosis is

QUESTION ID:4

Which of the following would cause deviation from the Hardy-Weinberg equilibrium ?

QUESTION ID:5

A woman who is a heterozygous carrier of an Xlinked recessive disease gene mates with a phenotypically normal male. The disease gene has a penetrance of 80%. On an average what proportion among the following of this couple’s sons will be affected with the disorder ?

QUESTION ID:6

In a certain tribal population of India, the prevalence of sickle cell disease, an autosomal recessive condition is 1/100. Based on this value, what proportion of the population would be heterozygous carriers of the sickle cell disease gene in that tribal population ?

QUESTION ID:7

Cell division cycle is divided into 4 phases G1, S, G2 and M. Standard eukaryotic cell cycles are of 12 h or longer duration. Early embryonic cell cycles are extremely rapid having time duration of less than an hour. Which of the following phases are drastically reduced in embryonic cell cycles?

QUESTION ID:8

Ballast water is a serious issue due to possibility of

QUESTION ID:9

White spot syndrome virus (WSSV) is a major shrimp viral pathogen. Among the WSSV structural proteins, VP28 protein located in the viral envelop plays a major role in invasion of WSSV into shrimp. What would be the ideal strategy for protection against the WSSV infection based on the above information?

QUESTION ID:10

When numbers of organisms and amounts of living material in successively higher trophic levels are compared, the values usually take the form of a pyramid, with the largest numbers and greatest biomass in the producer trophic level. However, in some marine ecosystems, the consumer trophic levels contain significantly greater amounts of living material than does the primary-producer trophic level. Which of the following is the best explanation for this?

QUESTION ID:11

Microbial rhodopsins are a widespread family of photoactive proteins. Archaebacteria belonging to Halobacteria predominantly contain

QUESTION ID:12

The Marshall hydrothermal recovery system is a patented proposal

QUESTION ID:13

Shellfish poisoning resulting in permanent short-term memory loss, brain damage and death in severe cases in humans is due to intake of

QUESTION ID:14

The most resistant population of mangroves which normally grow in high salinities inhabit the

QUESTION ID:15

Chitosan, a deacetylated form of chitin (a natural carbohydrate polymer in crab, lobster and shrimps) is used in medicine

QUESTION ID:16

A Slocum Glider, also referred to as an Autonomous Underwater Vehicle (AUV) is used at varying depths in marine waters

QUESTION ID:17

A marine bryozoan, normally causing a problem as a biofouler on boats, harbors a bacterium that has shown promise in cancer treatment as well as a memory enhancer for patients with Alzheimer’s. Choose the correct answer from the following.

QUESTION ID:18

Which of the following regions typically has the highest primary productivity per unit surface area of the ocean?

QUESTION ID:19

Biofilms interrupt the flow of ions and water to and from the substrate surface by acting as a diffusion barrier. The reduction of localised oxygen can accelerate the corrosion of a metallic substrate and is called microbially induced corrosion (MIC). An example of MIC is

QUESTION ID:20

Antifouling systems that do not use heavy metals are called foul release coatings (FRC).The most effective FRC presently used in the marine environment is

QUESTION ID:21

Porites from Scleractinian. (stony) .corals have been found to be biocompatible and hence used in human systems

QUESTION ID:22

The first marine derived anti-cancer drug, “Cytosar- U” used for the treatment of leukemia and lymphoma was isolated from

QUESTION ID:23

In a pairwise alignment, an optimal alignment is one that

QUESTION ID:24

FASTA was the first database search program that

QUESTION ID:25

RMSD between the coordinates of the amino acid gly and its mirror image after superposition will be

QUESTION ID:26

The radius of the following helix types in proteins follows the order

QUESTION ID:27

Needleman-Wunsch algorithm, is an example of dynamic programming, which does not involve

QUESTION ID:28

RCSB is

QUESTION ID:29

To identify the presence of repeats in a protein, the simplest and fastest way is to perform a

QUESTION ID:30

The double-helical Watson-Crick structure of DNA was first obtained form

QUESTION ID:31

Molecular dynamics differs from molecular mechanics by taking into account

QUESTION ID:32

Which of the following amino acid sequences belong to collagen fibers?

QUESTION ID:33

The secondary structural elements in a protein domain are in the sequence beta-beta-beta-alphabeta- beta-beta-alpha-alpha. It will be classified as

QUESTION ID:34

The major and minor grooves of B-form DNA correspond to the following feature of A-form RNA

QUESTION ID:35

Which is the amino acid among the following that can occupy positions in the Ramachandran map that are disallowed for other 19 amino acids, but allowed for D-amino acids?

QUESTION ID:36

If side chains of amino acids interact with each other, which of the following would be termed as a salt bridge?

QUESTION ID:37

Fifth order Markov model assumes that probability of occurrence of an element depends on

QUESTION ID:38

In a batch cultivation, during logarithmic growth phase, specific growth rate of culture virtually remains constant primarily because

QUESTION ID:39

The continuous High Temperature Short Time sterilization processes help in maintaining media quality primarily because of

QUESTION ID:40

Identify the parameter among the following used for scale up of a shear sensitive cells in a fermentation process

QUESTION ID:41

Sterilization of air by absolute filtration mechanism is primarily based on

QUESTION ID:42

In turbulent regime, power number is …………………the Impeller Reynolds number

QUESTION ID:43

When the carbon source used is changed from glucose to methanol in a bioprocess, you would definitely expect higher

QUESTION ID:44

Triglycerides are accumulated by several algal species, if

QUESTION ID:45

Acetobacter aceti produced 7.5 g/l CH3COOH from a medium containing initial 10 g/l C2H5OH when the residual C2H5OH concentration is 2 g/l. What will be the overall yield of CH3COOH from C2H5OH compared to the theoretical yield?

QUESTION ID:46

Exponential phase is between acceleration and deceleration phase of growth. The value of μ in both the phases except the exponential phase is

QUESTION ID:47

Cooling water enters at 20º C in a counter current heat exchanger and leaves at 40º C while hot water enters from the other side at 70º C and leaves at 50º C The LMTD for this process will be…………………(for calculating temperature difference in the equation Q = UA T).

QUESTION ID:48

Out of various derivatives of rifamycin groups of antibiotics, which one is biologically inactive

QUESTION ID:49

In a fed batch process with concentrated constant feed and high maintenance coefficient of the cells, growth of the cells will

QUESTION ID:50

Which of the following organisms typically get their carbon for biosynthesis from carbon dioxide

QUESTION ID:51

In centrifugation, if the angular speed is constant, the time required for pelleting cells in a rotor of larger size

QUESTION ID:52

Dynamic kinetic resolution yields a maximum of

QUESTION ID:53

Which of the following groups of enzymes is not used for the kinetic resolution of racemates?

QUESTION ID:54

In drug development, “Racemic switch” is introduced for the synthesis of

QUESTION ID:55

Which of the following pairs of amino acids is responsible for feed-back inhibition of lysine biosynthesis in Corynebacteria?

QUESTION ID:56

Which of the metal ions series is crucial in citric acid biosynthesis ?

QUESTION ID:57

In breakthrough curve for batch adsorption, steeper the curve_________ is the adsorbent

QUESTION ID:58

A 1.5 ml of a bacterial culture consisting of 108/ml is used to inoculate 100 ml of medium where the cells reach a density of 5x107 cells/ml. How many generations did the cells go through approximately?

QUESTION ID:59

Which of the following traits is most critical for a microorganism used in an industrial bioprocesses producing ethanol?

QUESTION ID:60

The degree for reduction of biomass CH1.8 N0.2O0.5 growing on glucose and ammonia is

QUESTION ID:61

The best example of product formation kinetics following Leudeking-Piret model is

QUESTION ID:62

The addition of silicone antifoam to a production fermenter has the disadvantage of

QUESTION ID:63

In a two-step fermentation process to produce vinegar, starting from molasses, the metabolic product produced as an intermediate is

QUESTION ID:64

For Monod equation with substrate inhibition given by μ= μm S/(KS+S+S2/KI), there are two theoretically possible steady state solutions in a CSTR. Out of these

QUESTION ID:65

The substrate concentration used in Monod kinetics is the

QUESTION ID:66

For high cell density cultivation of recombinant E. coli using fed batch techniques to maintain a constant specific growth rate, the feed of concentrated substrate is

QUESTION ID:67

In depth filtration, the material widely used is…………… fiber

QUESTION ID:68

In a fermentor without cooling coils and a single agitator if the height to diameter ratio is decreased,

QUESTION ID:69

The product concentration in an enzyme catalyzed reaction increases linearly with time. From this we can conclude that the

QUESTION ID:70

Generic drugs are introduced in the market as generic versions because they are

QUESTION ID:71

In an aerated bioreactor, the major increase in the oxygen transfer rate, when the stirrer speed is increased is because

QUESTION ID:72

Which of the following penicillins in current use represents an unmodified naturally occurring product?

QUESTION ID:73

A type of apomixis in which embryo sac develops from vegetative cells of the ovule is called

QUESTION ID:74

Banana bunchy top disease is transmitted by

QUESTION ID:75

The first product of photosynthesis in C3 plants is

QUESTION ID:76

Which one of the following requires back crossing?

QUESTION ID:77

nptII gene imparts resistance to

QUESTION ID:78

Agrobacterium mediated transformation of monocots requires the use of ______ for the induction of vir genes.

QUESTION ID:79

Which of the following techniques is used to obtain hybrids between two species with prefertilization barrier?

QUESTION ID:80

Which of the following is used most commonly in the plant tissue culture medium to induce multiple shoots ?

QUESTION ID:81

The chemical nature of GA3 is

QUESTION ID:82

Rice grains are deficient in

QUESTION ID:83

Lysimeter is used in the measurement of

QUESTION ID:84

Aerenchyma formation is related to which of the following hormones?

QUESTION ID:85

Barnase has----------activity

QUESTION ID:86

_______is used as a bacteriostat in the Agrobacterium mediated plant transformation experiments

QUESTION ID:87

Variation in clonally reproducing crop arises from

QUESTION ID:88

In the incomplete dominance of a monohybrid, the number of phenotypes in the F2 will be

QUESTION ID:89

Seeds germinating in dark beneath the surface of the soil undergo

QUESTION ID:90

The substrate for photorespiration is

QUESTION ID:91

Mating between individuals which are closely related by ancestry is called

QUESTION ID:92

 Engineering plants using chitinase gene leads to  development of 

QUESTION ID:93

The first GM potato developed at CPRI, India for increasing protein content in tubers consists of genes from

QUESTION ID:94

Hybridization between species followed by polyploidy is known as

QUESTION ID:95

Source of dwarfing genes in wheat is

QUESTION ID:96

Form of IPR that helped India win Basmati case is

QUESTION ID:97

The probable Geographic Origin of the following crops is called: Wheat and barley, flax, lentils, chickpea, figs, dates, grapes, olives, lettuce, onions, cabbage, carrots, cucumbers, melons and fruits and nuts

QUESTION ID:98

Administration of the DPT vaccine (diphtheria toxoid, pertussis products, and tetanus toxoid) would stimulate which of the following types of immunity?

QUESTION ID:99

Which of the following events occurs first in the differentiation sequence of human B cells in the bone marrow?

QUESTION ID:100

Loss of which of the following classes of molecules on the surface of a tumor cell target would result in loss of susceptibility to killing by host immune cells?

QUESTION ID:101

Which of the following cell types will be involved in an immediate hypersensitivity reaction due to an insect sting?

QUESTION ID:102

Which one of the following is NOT a function of glia?

QUESTION ID:103

Vagus nerve is a

QUESTION ID:104

Pain sensation is a subjective and conscious feeling. However, although the autonomic organs viz. brain, heart etc. do not get represented in the cerebral cortex, one feels pain in those parts as well. This is because

QUESTION ID:105

In a gastrocnemius-sciatic (nerve-muscle) preparation electrical stimulation of the nerve caused twitching of the muscle. Direct stimulation of the muscle also caused twitching. When curare (a cholinergic antagonist) was applied in the bath where the preparation was maintained and the nerve was stimulated, the muscle twitch was not seen. However, under these conditions, if the muscle was stimulated directly, it twitched. These observations suggest that

QUESTION ID:106

Nerve bundles in vertebrates are likely to contain

QUESTION ID:107

In Parkinson’s disease, there is a predominant loss of dopaminergic neurons primarily in

QUESTION ID:108

A tissue was responding when treated with a chemical for a brief period. However, when the treatment was continued for a longer time, the response stopped. After washing and leaving for some time, the tissue started responding to the same chemical at the same dose. The reason for the reduced response is likely to be due to

QUESTION ID:109

Salmons return to their specific home stream to spawn. This is an example of

QUESTION ID:110

Mark the correct statement for a normal living excitable cell at rest. The ionic concentrations across the cell membrane are such that

QUESTION ID:111

If the sequence of the DNA sense strand is 5’ GATCCTATGCTAC 3’, then the transcribed mRNA sequence will be

QUESTION ID:112

Which of the following cells is important for generation of antigen-specific effector T-cells?

QUESTION ID:113

Which one of the following cells does not require processed antigen to lyse tumour cells?

QUESTION ID:114

Cyclosporin A is administered to patients undergoing transplantation because it

QUESTION ID:115

In flow cytometry ‘compensation’ is used to remove

QUESTION ID:116

The binding of IL-2 to its receptor in an activated T- cell is mediated by

QUESTION ID:117

The D gene segment of the TCR and BCR encodes for a part of the

QUESTION ID:118

Super antigens bind to

QUESTION ID:119

ELISPOT assay is used for measuring

QUESTION ID:120

Latency is a feature of which one of the following viruses?

QUESTION ID:121

Which one of the following codons is used for selenocysteine during protein biosynthesis?

QUESTION ID:122

Which of the following mechanisms is useful for removal of autoreactive T-cells by the immune system?

QUESTION ID:123

In bovines which one of the following is a milk borne infection?

QUESTION ID:124

Which one of the following diseases in animals is eradicated from India?

QUESTION ID:125

Which one of the following diseases is contracted by human beings mainly through agricultural occupation?

QUESTION ID:126

COFAL test is used for the diagnosis of

QUESTION ID:127

Blue tongue virus

QUESTION ID:128

Buparvoquone is the drug of choice against

QUESTION ID:129

Which one of the following is not the characteristic of Aflatoxicosis in chick?

QUESTION ID:130

Vomiting, grey foul smelling diarrhea and gastroenteritis in young dogs are characteristics of

QUESTION ID:131

Most commonly affected species with papillomavirus is

QUESTION ID:132

The animal that excretes most of the virus in foot and mouth disease by aerosols even before the appearance of clinical signs is