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Previous Year Questions

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TLS Online TPP Program

QUESTION ID:1

Given below are two statements : One is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A) : Mycoplasma stains negative in Gram staining.
Reason (R) : Mycoplasma's cell wall is devoid of teichoic acid.
In light of the above statements, choose the correct answer from the options given below :

QUESTION ID:2

Which one of the following is responsible for development of myelin sheath in the central nervous system?

QUESTION ID:3

Which one of the following brain regions are NOT involved in eye movement control?

QUESTION ID:4

Which one of the following disorders leads to hallucinations?

QUESTION ID:5

In absolute refractory period of neurons

QUESTION ID:6

Phagocytosis in the central nervous system involves

QUESTION ID:7

What attribute do DREB transcription factors impart to higher plants?

QUESTION ID:8

Quantitative Trait Loci (QTL) can be mapped using

QUESTION ID:9

Given below a re two statements :
Statement I : Heterologous expression of prokaryotic genes in plants can be used to render resistance against insects.
Statement II : Expression of BtCry1Ac gene in cotton improves resistance against aphids.
In light of the above statements, choose the correct answer from the options given below :

QUESTION ID:10

Targeted gene disruption CANNOT be achieved by

QUESTION ID:11

Centimorgan (cM) is defined as the genetic distance between two loci with a statistically corrected recombination frequency of

QUESTION ID:12

Upon entering the cells, Cauliflower Mosaic Virus (CaMV) accumulates in inclusion bodies in which part of the cells?

QUESTION ID:13

Which one of the following genes provide herbicide tolerance?  

QUESTION ID:14

During cell cycle, genome replication occurs in 

QUESTION ID:15

Plant transformation method that uses tungsten or gold particle coated with DNA accelerated at a high velocity is called:

QUESTION ID:16

Which one of the following chemicals enhances vir gene expression in Agrobacterium? 

QUESTION ID:17

In monocot seedlings the highest concentration of auxin is found in the 

QUESTION ID:18

In plants, which stage of somatic embryo development requires ABA in culture medium?

QUESTION ID:19

A classical plant breeder wants to develop a disease resistant variety. What is the first step?

QUESTION ID:20

Which class of enzymes catalyzes the formation of oxalo -acetic acid from phosphoenol pyruvic acid in the chloroplasts of mesophyll cells?

QUESTION ID:21

Given below are two statements : One is labelled as Assertion A and the other is labelled as Reason R :
Assertion (A) : The major factors influencing the water potential in plants are solute concentration, pressure and gravity.
Reason (R): Turgor pressure in xylem vessel is responsible for generating the water potential.
In light of the above statements, choose the most appropriate answer from the options given below :

QUESTION ID:22

Which one of the following is the correct sequence of electron transfer in the thylakoid membrane during light cycle of photosynthesis?

QUESTION ID:23

Vinblastine and vincristine, the potent anticancer metabolites present in Catharanthus roseus, accumulate in which one of the following? 

QUESTION ID:24

Which one of the following is the immediate effect of ABA-dependent stomatal closure in plants?

QUESTION ID:25

The ABC model of flower development determines organ arrangement in the sequence sepal, petal, stamen and carpel. Due to the loss of Class A gene functions, the observed phenotype will be

QUESTION ID:26

Which one of the following enzymes is administered to dissolve blood clots during heart attack treatment?

QUESTION ID:27

Which one of the following anti-diabetic drugs is produced by coupling of GLP-1 peptide with lgG-Fc?

QUESTION ID:28

Match the enzymes in List I with their products items in List II:

Choose the correct answer from the options given below : 

QUESTION ID:29

Given below are two statements :
Statement I : Both aspirin and paracetamol belong to non -narcotic analgesics.
Statement II : The synthesis of prostaglandins, which stimulate inflammation in the tissue causing pain, is inhibited by aspirin.
In light of the above statements, choose the correct answer from the options below :

QUESTION ID:30

Given below are two statements :
Statement I : The manufacturing process of SARS-CoV-2 mRNA vaccine requires synthesis of mRNA from DNA using in vitro transcription.
Statement II : The naked mRNA is administered intramuscularly to the vaccine recipients to generate a protective immune response.
In light of the above statements, choose the correct answer from the options given below :

QUESTION ID:31

Saccharomyces cerevisiae was grown in batch fermentation mode to produce ethanol. The rate of ethanol production in the exponential phase was 2 g/L/h, which decreased to 1 g/L/h after sometime. Which of these is least likely to be responsible for this?

QUESTION ID:32

The aspect ratio (based on height & diameter) of a tower reactor is

QUESTION ID:33

The average molecular weight of a nucleotide base in oligonucleotides is 330. What would be the amount required to prepare 100 µL of 1 µM solution of a 20 bp long single stranded DNA?

QUESTION ID:34

Yeast are facultative anaerobes - they can grow anaerobically during alcoholic fermentation and aerobically using oxygen for cellular respiration. Interestingly, wild type yeast cannot live anaerobically using glycerol as their only fuel source. Which one of the following is the correct explanation ?

QUESTION ID:35

The pelleting of microsomal fraction from liver homogenate sample was performed using a centrifuge operated a t 15000 rpm. What is the angular velocity of centrifuge in rad/s?

QUESTION ID:36

Which one among the following CANNOT induce cell flocculation?

QUESTION ID:37

Which one of the following is the Del factor value for sterilizing a culture medium containing 1011 viable bacterial cells? 

QUESTION ID:38

Exponential growth of a bacterial culture in batch mode is usually defined by the equation dX/dt = µX, where µ is

QUESTION ID:39

During a fermentation process, the feed is sterilized using wet-heat sterilization method. What will happen to D-value, if the solute concentration in the feed increases by fourfold?

QUESTION ID:40

You have mixed 100 ml of 0.5 M solution of glucose and 200 ml of 0.5 M solution of glucose. The resultant solution will contain

QUESTION ID:41

The penicillin extraction process involves the following steps:
A. Extraction from the organic solvent into an aqueous buffer
B. Extraction from the aqueous buffer into an organic solvent
C. Extraction of penicillin from the filtered broth into organic solvent
D. Extraction of solvent to obtain penicillin salt
Choose the correct sequence of steps from the options given below :

QUESTION ID:42

Suppose that an obligate anaerobe suffered a mutation that resulted in the loss of triose phosphate isomerase activity. What will be the net ATP yield under anaerobic condition?

QUESTION ID:43

Which of the following processes can be utilized for sterilization of medium with heat sensitive components?

QUESTION ID:44

Bacillus polymyxa strain was cultivated under anaerobic condition in a media containing 10 g/L glucose as the sole carbon source. The glucose was completely utilized in 10 h producing 2, 3-Butanediol with productivity of 5 g/L/h. What is the yield of 2, 3- Butanediol produced per gram of glucose consumed (g/g)? 

QUESTION ID:45

If the partitioning coefficient (K) of a solute is 20 when it is extracted by an organic solvent from culture medium, what is the amount of solvent required per litre of culture medium to extract 90% of the solute in a single equilibrium stage? 

QUESTION ID:46

With respect to Good Manufacturing Practices and Process Safety, HACCP stands for

QUESTION ID:47

Which of the following ISO standards is designed for Food Safety Management?

QUESTION ID:48

Which of the following methods is used for rapid and accurate detection of toxic organisms in food?

QUESTION ID:49

An investigation of an outbreak of food poisoning following consumption of cultivated mussels showed the presence of a glutamate antagonist known as domoic acid in the body of the affected persons. What is the source of the domoic acid?

QUESTION ID:50

Which among the following bacteria is the most heat tolerant? 

QUESTION ID:51

The recent advancements in computing that has exponentially enhanced computing power for bioinformatics include

QUESTION ID:52

The researchers are looking for a possible DNA-binding groove in a protein structure. It is most likely to be a

QUESTION ID:53

Which one of the following CANNOT be used to determine the atomic structure of proteins?

QUESTION ID:54

Which one of the following represents the structure of silk protein fibroin?

QUESTION ID:55

Which one of the following amino acid residue pairs can disrupt α-helices?

QUESTION ID:56

Organic solvent acetone denatures proteins by 

QUESTION ID:57

The Levinthal paradox is related to 

QUESTION ID:58

Which one of the following does NOT assist protein folding?

QUESTION ID:59

The amino acid glycine is always present in

QUESTION ID:60

In α-helices, hydrogen bonds are formed in the polypeptide backbone between the -C=O group of the first amino acid and the

QUESTION ID:61

The number of base pairs present per helical turn in B-DNA is

QUESTION ID:62

Molecular Dynamics does NOT involve calculations of  

QUESTION ID:63

Alphafold is a protein folding algorithm based on

QUESTION ID:64

For phylogenetic analysis, which of the following is correct?

QUESTION ID:65

The following BLAST statistic does NOT change for same pair-wise alignments with different query databases; 

QUESTION ID:66

Which one of the following statements is correct?

QUESTION ID:67

Which one of the following is an example of a global alignment algorithm?

QUESTION ID:68

Which one of the following statements is correct?

QUESTION ID:69

The researchers are interested in solving the structure of a given protein through X-ray diffraction crystallography. Which one of the following types of proteins is likely to be more difficult to crystallize?

QUESTION ID:70

BLAST is popular tool to search for sequences similar to a given sequence (query) against a given database, and it often sorts resulting matches according to the e -value. Which one of the following statements is INCORRECT with respect to this e -value?

QUESTION ID:71

Johne's disease in ruminants is caused by 

QUESTION ID:72

Prolactin, the hormone that controls milk production is secreted by 

QUESTION ID:73

One health approach to address the challenge of Anti-microbial resistance involves addressing 

QUESTION ID:74

Somatic cell cloning involves transfer of

QUESTION ID:75

Sperm production is regulated by which one of the following cells of the seminiferous tubules

QUESTION ID:76

Ozone depletion is caused by increase in the level of 

QUESTION ID:77

The efficiency of an organic sludge composting method can be improved by various physicochemical options. Which one of the following is NOT a recommended option for the same?

QUESTION ID:78

A bacterium useful in bioleaching of low-grade mineral ores is 

QUESTION ID:79

Which of the following is NOT a ground water remediation technology? 

QUESTION ID:80

Find the t heoretical oxygen demand to completely oxidize 1.67 x 10-3 M glucose solution (C6H12O6) to CO2 and H2O. 

QUESTION ID:81

What mass of CO2 would be produced if 100 gm of butane (C4H10) is completely oxidized to CO2 and H2O? 

QUESTION ID:82

In India, which one of the following parameter is NOT a part of day -to-day Air Quality Monitoring? 

QUESTION ID:83

Which of the following is NOT a part of Integrated Solid Waste Management? 

QUESTION ID:84

Naupilus is a larval stage of 

QUESTION ID:85

Collagen is a source of 

QUESTION ID:86

Which of the following bioactive metabolites can be isolated from sea cucumbers?