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Previous Year Questions

TLS Online TPP Program

QUESTION ID:1

From a group of 7 women and 6 men, 5 persons are required to form a selection committee in which at least 3 women should be there. How many are the possibilities?

QUESTION ID:2

Two trains, one from Delhi to Pune and the other from Pune to Delhi, start at the same time from their respective stations. After they meet, the trains reach their appropriate destinations after 4 hours and 9 hours respectively. The ratio of their speeds is:

QUESTION ID:3

A container has a mixture of kerosene and water in a ratio of 7 : 5. When 9 litres of mixture are taken off and the container is filled with 9 litres of water, the ratio between kerosene and water becomes 7 : 9. How many litres of kerosene were initially in the container?

QUESTION ID:4

The missing number in the series 40, 120, 60, 180, 90, ___, 135 is

QUESTION ID:5

If a rectangle was called a circle, a circle a point, a point a triangle and a triangle a square, the shape of a wheel would be a

QUESTION ID:6

Six persons A, B, C, D, E and F are standing in a circle facing the centre of the circle. B is between F and C, A is between E and D, F is to the left of D. Who is between A and F?

QUESTION ID:7

The molecular weight of a protein is 30 kDa. The minimal length of mRNA encoding this polypeptide will be close to

QUESTION ID:8

What is the amount of protein required to prepare 5 ml of 1μM solution (Mol. Wt. of protein is 25 kDa)?

QUESTION ID:9

Calculate the concentration of NADH solution, whose A340nm = 0.8 O.D. (optical path length is 10 mm, NADH molar extinction coefficient is Ɛ340 = 6220)

QUESTION ID:10

Identify the pair that best expresses the relationship similar to that expressed in:
MENTOR:GUIDANCE

QUESTION ID:11

If counting was done in base 5 (instead of 10) so that 5 (in base 10) would be written as 10 (in base 5), 6 (in base 10) would be written as 11 (in base 5), then 89 (in base 10) will be written as which of the following numbers in base 5?

QUESTION ID:12

If there are 3 children in a family, then the probability that there is only one girl child in the family is

QUESTION ID:13

A students average marks (arithmetic mean) on three tests is 80. Which of the following CANNOT be the number of tests on which (s)he earned exactly 80 marks?

QUESTION ID:14

If 0<a<b<1,which of the following is INCORRECT?

QUESTION ID:15

If 25% of 260 equals 6.5% of 10a, what is a?

QUESTION ID:16

Complete the following sentence from the options provided. Few other plants can grow beneath the canopy of a tree, whose leaves and pods produce a natural herbicide that leaches into the surrounding soil, ___________other plants that might compete for water and nutrients.

QUESTION ID:17

The data below are from a Meselson-Stahl type of experiment. Which model of DNA replication is supported by the results shown in the table below? 

Generation

 % Heavy DNA

% Hybrid DNA

 % light DNA

   1

100

0

0

   2

50

0

50

   3

25

0

75

   4

12.5

0

87.5

QUESTION ID:18

How many triangles are present in this figure? 

QUESTION ID:19

A man goes to the house of Sita, who is the neighbor of Geeta, who has a daughter named Meera. Ashu is Aman’s father and is married to Anjali, who is sister of Geeta. How is Meera related to Anjali?

QUESTION ID:20

What will come in place of (*) in the following number series? 19, 26, 40, 68, 124 (*)

QUESTION ID:21

Fifty-three percent of a number is 358 less than the square of 26.What is the value of three-fourth of 23 per cent of that number?

QUESTION ID:22

A cube is painted on all sides using yellow and black color such that opposite faces are painted in different color. This cube is cut into 27 smaller cubes of equal sizes. How many smaller cubes will have only one face colored?

QUESTION ID:23

A man fills a basket with eggs in such a way that the number of eggs added on each successive day is the same as the number already present in the basket. This way the basket gets completely filled in 24 days. After how many days the basket was 1 / 4th full?

QUESTION ID:24

Seema goes 30 km towards North from a fixed point, then after turning to her right she goes 15 km. After this she turns right again and goes another 30 km. How far and in what direction is she from her starting point?

QUESTION ID:25

Find the odd one out:

QUESTION ID:26

Th1 response is characterized by the secretion of which of the following combinations of cytokines?

QUESTION ID:27

In hybridoma production, aminopterin is added after fusion to

QUESTION ID:28

An alpha-helical conformation of a globular protein can be determined by

QUESTION ID:29

The athymic nude (nu/nu) mice are difficult to breed and maintain because the homozygous (nu/nu) females are sterile. How will you propagate it to get maximum nude (nu/nu) mice progeny.

QUESTION ID:30

The base sequence of a short piece of DNA is AGCTTACG. During replication, a transition mutation occurs in the complementary strand synthesized on this piece of DNA. Which of the following is mutated complementary strand?

QUESTION ID:31

Uncoupling of LDL receptors with their ligands occur at which of the following compartments?

QUESTION ID:32

Transport of cargo from nucleus to cytoplasm through nuclear pore is regulated by

QUESTION ID:33

Which one of the following is a cobalt containing vitamin?

QUESTION ID:34

Brefeldin A inhibits protein transport from

QUESTION ID:35

Which one of the following diseases is caused by a bacteria ?

QUESTION ID:36

Which one of the following antibiotics is used to demonstrate the new/fresh protein synthesis in response to an inducer/ upon induction in a microbial system?

QUESTION ID:37

Both somatic hypermutation and isotype switching depend upon a highly specific enzyme of adaptive immunity that is made only by B cells proliferating in response to antigen. The name of the enzyme is

QUESTION ID:38

AGO proteins are associated with

QUESTION ID:39

The fusion between protoplasts can be enhanced by subjecting them to

QUESTION ID:40

If a nucleotide sequence encoding a protein is known and a homologous protein to be identified, which of the following will be the best analysis tool?

QUESTION ID:41

The concentration of which of the following plays an important role in somatic embryogenesis?

QUESTION ID:42

Simple sequence repeats (SSRs) markers are derived from

QUESTION ID:43

Which of the following enzymes are required for making plant protoplasts?

QUESTION ID:44

The floral dip method is commonly used for

QUESTION ID:45

Impeller Reynolds number is given by

QUESTION ID:46

Continuous cultivation is carried out in 10 L working volume. If 0.2 h-1 dilution rate has to be maintained, then the feed rate will be

QUESTION ID:47

If the doubling time of an organism is 0.693 h, the specific growth rate will be

QUESTION ID:48

Aeration in a fermentor is expressed as VVM. What will be the VVM if air is sparged at 2000 L/min with a working volume 10 m3?

QUESTION ID:49

Rate of centrifugation of a particle in a centrifuge is increased by

QUESTION ID:50

In a batch process of solvent-solvent extraction, higher percentage of extraction is ensured when the whole solvent for extraction is added

QUESTION ID:51

Which one of the following is true during the separation of biomolecules by reversed phase chromatography ?

QUESTION ID:52

In ultrafiltration, identify which one of the following relationships between transmembrane pressure (TMP) and flux (F) is CORRECT

QUESTION ID:53

Identify the INCORRECT match

QUESTION ID:54

The first smallpox vaccine is an example of

QUESTION ID:55

ELISPOT assay is traditionally used for measuring

QUESTION ID:56

Fertility factor’ is related to ‘conjugation’ in the same way as ‘bacteriophage P1’ to

QUESTION ID:57

Hemorrhage in the brain tissue with loss of consciousness is known as

QUESTION ID:58

Which one of the following methods is frequently used to create transgenic animals?

QUESTION ID:59

Which of the following is an atypical signaling receptor?

QUESTION ID:60

The critical regulatory site in the circuit of emotions is

QUESTION ID:61

Which glial cells participate in the re-uptake mechanism of neurotransmitter from the synaptic cleft?

QUESTION ID:62

Red data book contains data of ….

QUESTION ID:63

Conservation within the natural habitat is ……

QUESTION ID:64

MAB program stands for…

QUESTION ID:65

Marine organisms that require oxygen levels typically in the range of 2-10 % for growth would be classed under

QUESTION ID:66

Along which plate boundaries do the majority of the world's earthquakes occur?

QUESTION ID:67

Which of the following will increase the salinity of a particular area of coastal water?

QUESTION ID:68

An individual has the genotype AaBbccddEe. Assuming independent assortment what frequency of gametes will have the genotype abcde?

QUESTION ID:69

If the DNA content of a cell in G1 phase of cell cycle is ‘C’, what will be its content after meiosis is completed?

QUESTION ID:70

Which type of chemical mutagen is incorporated into the genome by DNA polymerase during replication?

QUESTION ID:71

Which of the following constitutes a necessary and sufficient condition for two proteins to be considered homologous?

QUESTION ID:72

Boiling a mixture of butter, water and eggs, results in a homogenous suspension; However if the eggs are omitted, then the butter and the water separate out. Which component, present in the egg, is responsible for this behaviour?

QUESTION ID:73

Cooking meat in presence of cut pieces of Papaya fruit results in unusually tender meat. What enzyme, present in the Papaya fruit is responsible for this?

QUESTION ID:74

Which of the following peptide sequences will match the sequence motif GXX[SVP]XXG?

QUESTION ID:75

In Mass Spectroscopy, a qudrupole mass filter does which of the following?

QUESTION ID:76

If maltose and monosodium glutamate (MSG) are added to a vinegar and palmitic acid and shaken, the mixture will eventually separate into two phases of different density and polarity. Where will most of the sucrose and the MSG be located following phase separation?

QUESTION ID:77

A slide of macrophage was stained by immunofluorescence using a monoclonal antibody for TAP1/TAP2 complex. Which of the following intracellular compartments would exhibit positive staining with this antibody?

QUESTION ID:78

Which of the following disorder is not X-linked?

QUESTION ID:79

α-amanitin inhibits

QUESTION ID:80

Nullisomy is the term used for the condition when an organism has

QUESTION ID:81

Tunicamycin blocks

QUESTION ID:82

Which of the following cannot be used in finding the interaction between miRNA and mRNA?

QUESTION ID:83

H1N1, H1N2, H2N1, H3N1 and H3N2 are subtypes of which influenza virus?

QUESTION ID:84

A mother and a father, both CF (cystic fibrosis) carriers, have two children that do not suffer from CF. The probability of a third pregnancy producing a child with the disease is

QUESTION ID:85

The overall reaction catalyzed by the electron transport chain is

QUESTION ID:86

DNA polymerase III of E. coli is

QUESTION ID:87

The protection against smallpox afforded by prior infection with cowpox represents

QUESTION ID:88

Internalized antigens are targeted to which of the following compartments for generation of appropriate peptide for presentation on the cell surface along with MHC molecule

QUESTION ID:89

In which receptor system, both receptor and ligand are recycled back to membrane

QUESTION ID:90

GTP binding proteins are active in GTP bound form. Which of the following protein coverts the GTP bound form to GDP bound form.

QUESTION ID:91

Which enzyme is used to remove the phosphate group from 5' end of the DNA?

QUESTION ID:92

Which one of the following techniques is suitable for the large scale purification of isozymes (A and B) that are differing from each other by a single positive charged amino acid?

QUESTION ID:93

Glycogen and cellulose are

QUESTION ID:94

Which one of the following factors influences the binding of oxygen to hemoglobin?

QUESTION ID:95

Which one of the following DNA viruses has part of its life cycle involving Reverse Transcriptase enzyme, which is a hallmark of Retroviruses?

QUESTION ID:96

Cells are broken to release the contents by using various enzymes. Which of the following combination is FALSE?

QUESTION ID:97

Which of the following enzymes is required to release the tension imposed by uncoiling of strands?

QUESTION ID:98

DNA fingerprinting is based on

QUESTION ID:99

The DNA sequence is ATG. What would be the sequence of bases in anticodon of tRNA

QUESTION ID:100

All except one of the following are true about the protein kinase A (PKA) pathway

QUESTION ID:101

A T- cytotoxic cell can be induced to mount a cytotoxic attack on a virus-infected cell if it binds to a cell displaying

QUESTION ID:102

Testosterone hormone, necessary for spermatogenesis, is secreted by

QUESTION ID:103

Which of the following processes occurs in the formation of disulfide bridge between two cystiene residues?

QUESTION ID:104

In Ramachandran plot, the values of the dihedral angle ψ (psi) is based on rotation around

QUESTION ID:105

Which one of the following antibiotics attaches to 50S ribosome and inhibits peptidyltransferase activity?

QUESTION ID:106

The cytological representation of Klinefelter syndrome is

QUESTION ID:107

A chromosome on which T-cell receptor alpha chain gene rearrangement has occurred lacks which of the following gene segments?

QUESTION ID:108

Which one of the following molecule yields higher amount of free energy?

QUESTION ID:109

Which region of mRNA contains Shine-Dalgarno sequence?

QUESTION ID:110

α-D glucose and β-D glucose are

QUESTION ID:111

Which of the following statements is NOT true for eukaryotic DNA replication?

QUESTION ID:112

In vitro characterization of E. coli DNA polymerase shows an error rate of 10-6 -10-7 per base pair. However, in vivo, the observed mutation rate is 10-9 -10-10 per base. Such discrepancy is because:

QUESTION ID:113

The molecular formulae of deoxyribose sugar and ribose sugar, respectively, are

QUESTION ID:114

Usually intracellular pathogens avoid their transport to lysosome for their survival in the host cell. But which of the following intracellular pathogens survives in the lysosomes?

QUESTION ID:115

When Hfr strain of E. coli is crossed with F- strain, recombinant obtained are

QUESTION ID:116

Archea is considered as a separate group from bacteria and eukaryotes, based on

QUESTION ID:117

How many grams of NaCl will be required to make 10 ml of 10 millimolar solution (MW of NaCl = 58.5)

QUESTION ID:118

Keratin intermediate filaments are synthesized in the cytoplasm of cells. Disulfide bonds cannot be formed in the cytoplasm. However, the keratin fibers in the skin are cross-linked by disulfide bonds. This is because

QUESTION ID:119

Which of the following plays a role in changing the antigen binding site of a B cell after antigenic stimulation?

QUESTION ID:120

What region of an mRNA is most commonly associated with transcript destabilization?

QUESTION ID:121

Which type of replication requires a break in the nucleotide strand to get started?

QUESTION ID:122

Mismatch repair in bacteria distinguishes between old and new strands of DNA on the basis of

QUESTION ID:123

Why does the Environmental Protection Agency closely monitors the release of transgenic bacteria used for agricultural purposes?

QUESTION ID:124

Which of the following events occurs first in the differentiation sequence of human B cells in the bone marrow?

QUESTION ID:125

A zoo blot helps to detect DNA sequences that

QUESTION ID:126

Addition of which of the following can prevent the precocious germination of the embryos during embryo culture?

QUESTION ID:127

Which of the following techniques can be used to create diploid homozygous plants in a short span (few months to a year)?

QUESTION ID:128

In plant tissue culture experiments, “conditioned medium” refers to a medium in which

QUESTION ID:129

An intron containing β-glucuronidase (gus-intron) is used as a reporter gene to assess plant transformation. The intron is introduced to:

QUESTION ID:130

Which one of the following is true about epigenetic changes?

QUESTION ID:131

A cross between two true breeding lines, one with dark blue flowers and the other with bright white flowers produces F1 offspring that are light blue. When the F1 progenies are selfed, a 1:2:1 ratio of dark blue to light blue to white flowers is observed. What genetic phenomenon is consistent with these results?

QUESTION ID:132

In a tissue culture experiment, a student desires to have more differentiation of shoots. Which of the following plant growth hormone ratios should be used?

QUESTION ID:133

A yeast mutant shows decreased expression of 5.8S rRNA, 5S rRNA and cdc2 mRNA. In which of the following might mutation lie?

QUESTION ID:134

Photosynthesis is a:

QUESTION ID:135

Which of the following statements about a genomic library is INCORRECT?

QUESTION ID:136

Which one of the following statements CORRECTLY describes the sequential steps in cDNA cloning?

QUESTION ID:137

Hygromycin B, generally used as a selection marker in plant transformation protocols is

QUESTION ID:138

Which of the following statements about transcription in E. coli is CORRECT?

QUESTION ID:139

In an in vitro culture experiment the colour of explants turned brown just after 24 hours of sub-culturing. This is due to the

QUESTION ID:140

To avoid the somaclonal variation in the development of transgenic plants which one of the following is preferred?

QUESTION ID:141

The transplastomic lines have no risk of gene escape through pollens since the

QUESTION ID:142

Among the following, which one is NOT a common method of haploid plant production?

QUESTION ID:143

Which one of the following statements about the M13 bacteriophage is INCORRECT?

QUESTION ID:144

Which of the following are flowering hormones?

QUESTION ID:145

Which of the following genes are constitutively expressed and control the plantinduced activation of other vir genes?

QUESTION ID:146

In case of gametophytic incompatibility system, the self incompatibility phenotype of the pollen is determined by

QUESTION ID:147

High frequency heterokaryon formation is observed during protoplast fusion by the addition of

QUESTION ID:148

Somatic embryo induction generally occurs in presence of the two growth regulators namely

QUESTION ID:149

A molecular biology student genetically engineered Arabidopsis thaliana to harbour bar gene. The resulting transgenic plant is expected to be resistant to

QUESTION ID:150

Which one of the following statements about haploids is INCORRECT?

QUESTION ID:151

Refugia approach in cultivation of Bt cotton is used to minimize

QUESTION ID:152

In which method of plant transformation would multicopy integration be a common feature?

QUESTION ID:153

Which one of the following techniques will help to overcome a pre fertilization barrier between the two species?

QUESTION ID:154

Genes located in which one of the following do not follow Mendel’s laws?
(i) Nucleus
(ii) Choloroplast
(iii) Mitochondria
(iv) Cytoplasm

QUESTION ID:155

Seedless fruits may arise as a result of

QUESTION ID:156

An aluminium pot contains water that is kept steadily boiling (100 °C). The bottom surface of the pot, which is 0.012 m thick and 1.5 x 104 mm2 in area, is maintained at a temperature of 102 °C by an electric heating unit. Find the rate at which heat is transferred through the bottom surface. Given kAl = 235 W.m-1.K-1

QUESTION ID:157

What happens to the viscosity of non-Newtonian fermentation broth upon scale-up?

QUESTION ID:158

Estimate the theoretical growth yield coefficient (Y xs) for ethanol fermentation by S. cerevisiae as described by the following overall reaction: 

Given Y xmw =10.5 gdw/mol ATP and glycolysis yields 2ATPhnol of glucose in Yeast 

QUESTION ID:159

Which one of the following is true in the scale-up of medium sterilization?

QUESTION ID:160

In order to extract Penicillin G from fermentation broth, the pH of the broth is adjusted to pH 2.5. This is done because:

QUESTION ID:161

Dynamic kinetic resolution of a racemic mixture of alcohol ensures its ______ percent conversion to one enantiomer:

QUESTION ID:162

Very low values of Km may cause

QUESTION ID:163

In the stoichiometric equation given below identify which one of the following corresponds to oxygen balance:
CwHxOyNz + aO2 + bHgOhNi ―> c CHαOβNδ + dCO2 + eH2O

QUESTION ID:164

If the ΔG of the reaction A → B is –40 kJ/mol, under standard conditions the reaction

QUESTION ID:165

Salting out of proteins results in

QUESTION ID:166

The specific productivity (qp) of an enzyme production is fitted linearly with specific growth rate (μ) of a fungal organism according to the equation qp = α.μ + β. The estimated values of constants α and β are 0.0006 and 25 respectively. The enzyme production kinetics is

QUESTION ID:167

The partition coefficient of a solute between the stationary phase and the mobile phase is denoted by the

QUESTION ID:168

A fermentor with volume V is vigorously agitated with an impeller of diameter Di, rotating at an rpm of n. Mixing time tm in the reactor maximally decreases with

QUESTION ID:169

Identify which one of the following is true of a typical drying curve

QUESTION ID:170

Upon addition of reversible inhibitors to an enzymatic reaction following MM kinetics, the following velocity profiles are generated as shown in the figure below (indicated in Red, green and blue line). The red line velocity profile indicates that the reaction is 

QUESTION ID:171

Common name for Hexadecanoic acid is

QUESTION ID:172

The interaction between a solute and a solvent is determined by the balance of forces between solvent molecules, between solute molecules and between solute and
solvent molecules. If the sum of two self-interactions balance the cross-interactions, the solvent is referred to as a(n)

QUESTION ID:173

Given in the table is the list of compounds being produced by the organisms. With appropriate matching indicate which one of the following combinations is most appropriate. 


QUESTION ID:174

One advantage of using Pichia pastoris as a protein expression platform over Saccharomyces cerevisiae is that the former

QUESTION ID:175

The synthesis of aspartame may be carried out in organic solvents using

QUESTION ID:176

The water content in solid state fermentation is

QUESTION ID:177

When considering submerged fermentation system oxygen transfer is considered to be a more important factor than the supply of other nutrients. Which one of the following statements is correct?

QUESTION ID:178

Which one of the following sugars is not only non-reducing sugar but also does not exhibit muta-rotation

QUESTION ID:179

Calculate the overall order of a reaction which has rate expression: Rate = k [A]1/2 [B]3/2

QUESTION ID:180

Match the microbial enzymes from Group A with appropriate application processes from Group B 

QUESTION ID:181

Which one of the following statements is FALSE. Microbial secondary metabolites are

QUESTION ID:182

Rate of centrifugal sedimentation is a

QUESTION ID:183

The advantage of chemostat with cell recycle system over a simple chemostat is that it can be

QUESTION ID:184

Which one of the following amino acids is the most effective contributor of protein buffer?

QUESTION ID:185

Fluorescence microscopy is based on the ability of certain molecules to

QUESTION ID:186

Hemorrhagic lymphadenitis is seen in

QUESTION ID:187

In equine infectious anemia, central nervous system shows

QUESTION ID:188

Hjarre’s disease in poultry is caused by

QUESTION ID:189

After infection of cattle, Dictyocaulus viviparus larvae reach the lungs via

QUESTION ID:190

Which one of the following is found in overloaded rumen?

QUESTION ID:191

Pressing of head against wall by cow is the clinical symptom of

QUESTION ID:192

Which one of the following factors released from damaged tissue initiate a chain of clotting events?

QUESTION ID:193

Which one of the following breeds of cattle is known as a milch breed?

QUESTION ID:194

Tarry color blood from natural orifice is a symptom of

QUESTION ID:195

Which one of following cartilages lacks a distinct perichondrium in horse?

QUESTION ID:196

Creutzfeldt-Jakob disease is caused by

QUESTION ID:197

The natural reservoir of Ebola virus is

QUESTION ID:198

A disease diagnostic assay with high specificity should yield

QUESTION ID:199

Which one of the following statements is INCORRECT for cystic fibrosis?

QUESTION ID:200

Drug resistance among bacteria involved in hospital infections is commonly due to

QUESTION ID:201

Vaccine is available for all except one of the following pathogens

QUESTION ID:202

Toxic shock syndrome is caused by

QUESTION ID:203

BCG vaccine______________

QUESTION ID:204

Which one of the following is commonly used to prevent microbial growth in polyclonal sera?

QUESTION ID:205

The prescribed treatment for swine flu is

QUESTION ID:206

A chimeric therapeutic monoclonal antibody consists of

QUESTION ID:207

Match the microbial enzymes from Group A with appropriate application processes from Group B

QUESTION ID:208

Which one of the following is INCORRECT about Fragile X syndrome?

QUESTION ID:209

Which one of the following statements is true about superantigens?

QUESTION ID:210

Retrograde transport may be used for

QUESTION ID:211

The conscious state of an individual may be best understood by studying ones

QUESTION ID:212

Acetylcholine is released by exocytosis of synaptic vesicles; this release is triggered by

QUESTION ID:213

Resting membrane potential of a neuron range between

QUESTION ID:214

The pathological hallmark of Huntington’s disease is

QUESTION ID:215

The patterning of the nervous system along the anterior-posterior axis in embryo is controlled by

QUESTION ID:216

Approximately, 50% of total world plant species are present in…

QUESTION ID:217

The process of mineralization of environmental pollutants by wild microbes is referred as …

QUESTION ID:218

Which one of the following is readily available source of nitrogen to plant?

QUESTION ID:219

Root nodules are pink due to ….

QUESTION ID:220

Which of the following is a GM phytoremediator plant?

QUESTION ID:221

Which one of the following terms represents the recycling of settled decomposer bacteria in sewage treatment plant?

QUESTION ID:222

The relationship between species A and species B is described as commensalism. This means that…..

QUESTION ID:223

Which one of the following is the best indicator of SO2 pollution?

QUESTION ID:224

Which one of the following groups of enzymes is primarily involved in microbial bioremediation?

QUESTION ID:225

Why catalase is induced in microbes during exposure to the pollutants?

QUESTION ID:226

The solute concentration of the body fluids of some marine organisms are maintained the same as that of the external medium in which the organism lives. Such organisms are referred to as

QUESTION ID:227

Remote sensing is done in the microwave channels by virtue of

QUESTION ID:228

Which of the following drugs was not isolated from a natural source?

QUESTION ID:229

Antifreeze molecules that prevent intracellular ice formation in marine organisms are generally

QUESTION ID:230

Which term refers to the distance that the wind travels across open water?

QUESTION ID:231

The typical residence time of water in the oceans is of the order of

QUESTION ID:232

The spring bloom of phytoplankton in the surface waters of high latitude oceans occurs when

QUESTION ID:233

The vertical movement of lithosphere to accommodate additional weight or removal of weight is called

QUESTION ID:234

Which family of motile bacteria with polar flagella is predominant in coastal and marine environments?

QUESTION ID:235

Which is the oceanic zone that extends from the low tide line to the edge of the continental shelf?

QUESTION ID:236

Evidence of past climate conditions is best revealed by studying

QUESTION ID:237

The gases making highest relative contribution to “green house gases” are

QUESTION ID:238

Which of the following types of coral reefs (given below as 1-3) are found in India?
1. Atoll
2. Fringing
3. Barrier

QUESTION ID:239

What part of a tidal cycle has minimal current?

QUESTION ID:240

What is the function of nucleators in freeze-tolerant animals?

QUESTION ID:241

The first marine derived cancer drug, “Cytosar-U” used for the treatment of leukemia and lymphoma was isolated from

QUESTION ID:242

Altemicidin isolated from Streptomyces sioyaensis SA 1758 has antitumor activity and has been widely used in aquaculture

QUESTION ID:243

A marine bryozoan, normally causing a problem as a biofouler on boats, harbors this bacterium that has shown promise in cancer treatment and also as a memory enhancer for patients with Alzheimer’s disease:

QUESTION ID:244

A system incorporating unilateral eye stalk ablation, high salinity, good water quality and optimum temperature can

QUESTION ID:245

Which of the following can help determine if two mutations are allelic?

QUESTION ID:246

Which of the following can help determine if two mutations are allelic?

QUESTION ID:247

An individual has the genotype AaBb. The two genes are linked in cis and is 5cM apart. What percentage of gametes will have the genotype ab?

QUESTION ID:248

An E. coli mating between Hfr trp+ his+ strS and F-trp- his- strR was allowed to proceed for 30 minutes. The mixture was plated on medium containing either (i) streptomycin + histidine or (ii) streptomycin + tryptophan. Replica plating revealed that in the first case ‘i’ 48 out of 104 colonies were his- while in the second case ‘ii’ 10 out of 70 colonies were trp-. Which of the following is the best representation of the location of the trp and his genes relative to the origin of transfer (>) of the Hfr chromosome?

QUESTION ID:249

Color blindness is an X- linked recessive character. A color blind man and his wife with normal vision have a colour-blind daughter. What is the probability that their new born son would be colour-blind?

QUESTION ID:250

Alkaptonuria is a metabolic disorder controlled by a recessive autosomal allele. The frequency of Alkaptonuria in an ethnic population is about 1 in million persons. What is the proportion of heterozygous ‘carriers’ in the population?

QUESTION ID:251

Of a population of cells undergoing meiosis, 1% of the cells undergo recombination between genes A and B. What is the distance between the two genes?

QUESTION ID:252

Variation in which types of repeat sequence commonly arise by replication slippage?

QUESTION ID:253

One form of congenital deafness in human is inherited as a recessive condition and controlled by two independent genes (A and B). In the pedigree depicted below, two deaf individuals have children with normal hearing ability. 

What would be the probable genotypes of the deaf parents? 

QUESTION ID:254

Genetic relatedness between mothers and daughters in haplodiploid organisms is

QUESTION ID:255

In a family, among the siblings, there is a heterozygous girl for haemophilia, a normal boy, a haemophilic girl and a haemophilic boy. Which of the following genotypes would be attributed to the parents?

QUESTION ID:256

Which among the following is a proper definition of a SMILES string ?

QUESTION ID:257

Which of the following is a correct statement regarding sensitivity and specificity of a search algorithm?

QUESTION ID:258

Which of the following statements is true for the BLAST algorithm for sequence comparison?

QUESTION ID:259

A mixture containing L-Aspartate, D-Aspartate and L-Lysine was set up for crystallization and produced a single crystal belonging to space group P2/m (Primitive cell with a 2-fold rotation axis and a mirror plane perpendicular to the rotation axis). Which of the following is the most likely composition of the crystal?

QUESTION ID:260

Which of the following statements best describe the significance of the Temperature factor (B-factor) column in a PDB file?

QUESTION ID:261

Peaks in 1H-NMR spectra are often split into multiplets due to spin-spin coupling with neighbouring protons. Surprisingly, peaks in 13C-NMR spectra appear much simpler with very little evidence of 13C-13C coupling. Which one of the following statements offers the best explanation for the above observation?

QUESTION ID:262

For any molecule with N atoms (N > 3), the minimum number of internal coordinates (bond lengths, bond angles and dihedral angles) sufficient to describe the structure of the  molecule is given by:

QUESTION ID:263

A scientist screening for monoclonal antibodies against a protein antigen isolates two antibodies, the first of which recognizes a conformational epitope in the form of an α- helix in the protein, and a second one that also recognizes a conformational epitope, but in the form of just one strand in a multi-stranded β-sheet. The scientist then synthesizes small peptides with the same sequences corresponding to the two epitopes and tests for binding with antibodies. Which of the following is the most likely outcome of her experiments?

QUESTION ID:264

Which of the following cases will most likely lead to sequence specific recognition of DNA by a protein?

QUESTION ID:265

Which of the following algorithms is most likely to be used as an optimizer for Docking calculations?

QUESTION ID:266

A certain chemical carcinogen causes a lethal chemical modification in DNA bases with a probability of 10-7. It was found that if cultured human cells are treated with this compound then approximately 1% of the amount added makes its way to the nucleus and attacks the chromosomes. What is the approximate probability of obtaining at least one base modification event per cell, if cultured human cells are treated with the compound at a concentration of 1mmol/cell.

QUESTION ID:267

When p and q are lengths of sequences, the computational complexity of the Smith- Waterman algorithm is

QUESTION ID:268

Which among the following is a measure of similarity between two chemical structures of small molecules?

QUESTION ID:269

A closed circular DNA molecule is treated with saturating concentrations of an intercalator followed by treatment with topoisomerase until it is completely relaxed. If the intercalator is now removed by dialysis, the DNA molecule will become

QUESTION ID:270

Which among the following amino acids has at least ONE asymmetric carbon atom in its side-chain?

QUESTION ID:271

A right handed α-helix made up of L-amino acids has φ,ψ angles of -60 and -40 degrees respectively. Which of the following will be the φ,ψ angles of a left handed α-helix made up of D-amino acids only?

QUESTION ID:272

The membrane permeability of Dimethyl urea is:

QUESTION ID:273

Which of the following statements is true with respect to the formation of disulfide bonds in a protein produced by eukaryotic cells?

QUESTION ID:274

Circular dichroic spectra of some proteins show a strong negative ellipticity band at 200 nm. Which of the following secondary structures is characterized by the presence of this band?

QUESTION ID:275

Water has a high dielectric constant of 80 in contrast with many non-polar solvents having very low dielectric constants. Due to this property the electrostatic interactions between various side-chains of amino acids in proteins after their transfer from nonpolar solvent to water would: