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Previous Year Questions

TLS Online TPP Program

QUESTION ID:1

Find the next number(?) in the following series.
9, 15, 25, 39, 57, ?

QUESTION ID:2

Rita is as many years younger to Sita as she is older to Mita. Sita's age 4 years hence will be equal to Mita's age 10 years later. Sita is how many years older to Mita ?

QUESTION ID:3

A man riding a bicycle completes one lap of a circular field along its circumference at the speed of 14.4 km/h in 1 min 28 s. What is the area of the field?

QUESTION ID:4

When 10 ml of 0.1 M H2SO4 is slowly added to 10 ml of 0.2 M KOH, how will the pH of the mixture change over time ?

QUESTION ID:5

Identify the odd one out.

QUESTION ID:6

P and Q undertake to do a work for ₹ 400. P alone can do this work in 4 days while Q alone can do it in 8 days. With the help of R, they finish the work in 2 days. Find R's share in ₹ in this deal.

QUESTION ID:7

Given below are two statements :
Statement I : Bleeding gums is the symptom of scurvy.
Statement II : Scurvy is caused due to the deficiency of ascorbic acid.

In light of the above statements, choose the correct answer from the options given below:

QUESTION ID:8

Area of a symmetrical hexagon having each side of 2 cm is equal to

QUESTION ID:9

40% of the people read newspaper X, 50% read newspaper Y and 10% read both the newspapers. What percentage of the people read neither X nor Y?

QUESTION ID:10

Ajay and Sumit participated in head boy election of their school. Ajay got 56% of the total votes polled and won the election by 240 votes. How many students voted, if no vote was invalid?

QUESTION ID:11

In a certain code language, 576 means 'flower is red' , '74' means red colour, and 486 means 'colour is fun'. Which of the following digits in that language means 'fun'?

QUESTION ID:12

Which of the following statement(s) is correct about RuBisCo?
A. It functions in photosynthetic electron transport.
B. It catalyzes the fixation of CO2 into its organic form.
C. It is found only in the green plants capable of photosynthesis.
D. It catalyzes the binding of CO2 to the ribulose 1,5-bisphosphate.

Choose the correct answer from the options given below :

QUESTION ID:13

Which one of the following is NOT an obligate intracellular parasite and therefore can be grown on bacteriological media?

QUESTION ID:14

In a row of girls, P is at the 20th position from the left and Q is at the 7th position from the right. There are three girls between P and Q. 'R' is just left of 'P'. What is the position of 'R' from the right?

QUESTION ID:15

Find out the number of triangles in the given figure ?


QUESTION ID:16

Formation of ATP from ADP and Pi occurs during
A. oxidative phosphorylation (in mitochondria)
B. photophosphorylation (in leaf)
C. reductive phosphorylation (in mitochondria)
D. esterification
E. phosphoramidation

Choose the correct answer from the options given below :

QUESTION ID:17

Which of the following compounds is the weakest acid?

QUESTION ID:18

An old man's daughter is Rita's daughter's aunt. What relation does the old man have with Rita's daughter?

QUESTION ID:19

Which alphabet lies in all the three geometrical figures given below ?


QUESTION ID:20

The word pair "Newspaper : Press" has certain relationship. Select a word having similar relationship with the word "Cloth".

QUESTION ID:21

What will come in place of the question marks(?, ?) in the following series?
Z, A, X, D, V, G, T, J, ?, ?

QUESTION ID:22

Arrange the following words in a meaningful order.
A. Pond
B. Sea
C. Ocean
D. Lake

Choose the correct answer from the options given below.

QUESTION ID:23

If Ram purchases 10 oranges for ₹ 25 and sells 9 oranges for ₹ 25, then find the gain percentage.

QUESTION ID:24

Match List I with List II: 

    List I                                        List II 

A. Clostridium botulinum     I. Probiotic 

B. Bacillus spp.                      II. Biofertilizer 

C. Azospirillum                     III. Cosmetic treatment 

D. Lactobacillus                   IV. Bioremediation 


Choose the correct answer from the options given below:

QUESTION ID:25

If 4th Saturday of the month of 30 days was 23rd, then what was the 15th day of the month?

QUESTION ID:26

June 4, 2002 falls on Tuesday. What day of the week it was on June 4, 2001 ?

QUESTION ID:27

The interior angles of a regular polygon with 10 sides are

QUESTION ID:28

The traffic lights at three different road crossings change after every 48 s, 72 s and 108 s, respectively. If they change simultaneously at 8:20:00 h, when will they again change simultaneously?

QUESTION ID:29

In how many ways can 20 persons be seated around a circular table ?

QUESTION ID:30

Which of the following amino acids limits the flexibility in the polypeptide chain in proteins?

QUESTION ID:31

Match List I with List II: 
  List I                                             List II 
A. Exons                                 I. DNA sequence that provides binding sites for RNA polymerase 
B. Promoter                           II. Polynucleotide phosphorylase 
C. Severo Ochoa enzyme   III. DNA dependent DNA polymerase 
D. DNA replication              IV. Sequences in spliced RNA 

Choose the correct answer from the options given below:

QUESTION ID:32

The process of degradation of humus by microbes and release of inorganic nutrients is

QUESTION ID:33

If first day of a 31-day month is Monday, then which day of the next month will be the second Saturday?

QUESTION ID:34

Find the missing term(?) in the given series.
2, 9, 28, 65, ?, 217, 344

QUESTION ID:35

What are the alphabets which are present in at least two of the options given below ?

QUESTION ID:36

A computer was sold for ₹ 20230 after applying two discount offers of 20% on marked price followed by 15% festival offer on the resulting price obtained after applying the first offer. What is the marked price of the computer ?

QUESTION ID:37

Which of the following stains can be used to microscopically detect Plasmodium spp. in the blood smears of infected individuals ?

QUESTION ID:38

At constant temperature, the pressure of a fixed amount of gas is inversely related to its volume. This is known as

QUESTION ID:39

Which of the following statements is true for histones ?

QUESTION ID:40

What is the pH of a solution containing 0.3 M acetic acid and 0.05 M sodium acetate ?  (Ka = 1.75 x 10-5)

QUESTION ID:41

Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R.
Assertion A: Solubility of alcohols in water decreases with increase in size of the alkyl groups.
Reason R: Alcohols are soluble in water due to hydrogen bonding.

Choose the most appropriate answer from the options given below :

QUESTION ID:42

If A x B means A is the sister of B, A + B means A is the father of B, and A - B means A is the mother of B, which of the following means P is the aunt of Q?

QUESTION ID:43

In a certain code, MANAGER is written as 'QDFZMZL'. How will JUNGLE be written in that code?

QUESTION ID:44

In Sanger sequencing reaction , the exact function of the dideoxynucleotides is

QUESTION ID:45

What will be the angle between the hands of the clock at 21 :30 hrs ? Choose the closest value.

QUESTION ID:46

Among the allotropes of carbon, _____ is the hardest natural substance known, while _____ has layered sheet structure.

QUESTION ID:47

In a row of girls, there are 10 girls between Rama and Lakshmi. Rama's position is 42nd from the right end. If Rama is nearer than Lakshmi to the left end of the row, then how far is the Lakshmi's position from the right end of the row?

QUESTION ID:48

Pointing to a man in the picture, Meena said, "his mother has only one grandchild whose father is my husband". How is the man in the picture related to Meena ?

QUESTION ID:49

Find the wrong number in the following series.
1, 3, 10, 43, 206, 1237

QUESTION ID:50

Rohan walks 28 km towards North from his home. From there, he walks 20 km towards South. Then he walks 6 km towards West. How far and in which direction is he now from his home?

QUESTION ID:51

What is the concentration of H+ in a solution of 0.1 M NaOH?

QUESTION ID:52

In the semi-conservative mode of DNA replication , what percentage of double-stranded DNA would consist of one original parent strand and one daughter strand after three rounds of DNA replication?

QUESTION ID:53

The mRNA sequence corresponding to the template DNA sequence 5'-ATGATGATGTGA-3' would be

QUESTION ID:54

Which of the following monoclonal antibodies is NOT used in cancer treatment?

QUESTION ID:55

Which of the following pathological conditions is NOT a consequence of the disruption of nucleotide metabolism ?

QUESTION ID:56

Cystic fibrosis disease is caused by a mutation in the gene coding for

QUESTION ID:57

Vancomycin (S = 0.87) has to be infused intravenously into a 70 kg patient suffering from S. aureus infection. Given that Vancomycin has the following volumes: volume distribution at time zero (V 1) = 0.5 L/kg and volume distribution at steady state (Vdss) = 1.3 L/kg. What should be the loading dose to achieve 2 mg/L plasma vancomycin concentration?

QUESTION ID:58

Match List I with List II: 
  List I                             List II 
A. Berberine          I. Papaver somniferum 
B. Vincristine         II. Coptis japonica 
C. Morphine           III. Catharanthus roseus 
D. Pyrethrin           IV. Chrysanthemum cinerariaefolium 

Choose the correct answer from the options given below:

QUESTION ID:59

Hypnozoites are majorly found in malarial infection caused by

QUESTION ID:60

Which enzyme is responsible for the reduction of atmospheric gaseous nitrogen to ammonia in biological nitrogen fixation?

QUESTION ID:61

Ethidium bromide is a commonly used stain for DNA molecules during gel electrophoresis. How does it stain the DNA?

QUESTION ID:62

Match List I (pathogen species name) with List II (effector name) 
   List I                                                                  List II 
A. Tobacco mosaic virus (TMV)                  I. AvrPto 
B. Pseudomonas syringae pv. Tomato      II. Avr2 
C. Cladosporium fulvum                              III. Avr3a 
D. Phytophthora infestans                          IV. P50 

Choose the correct answer from the options given below 

QUESTION ID:63

The protein folding landscape is often depicted as a funnel. Where the circumference of the funnel represents all the possible starting conformations of the protein before it starts folding. The Y-axis in this funnel depicts the

QUESTION ID:64

Following are the strategies available to elute a protein of interest from an anion exchange column
A. Increasing the dielectric constant of the eluting solution.
B. Decreasing the dielectric constant of the eluting solution.
C. Increasing hydrophobicity of the eluting solution.
D. Decreasing hydrophobicity of the eluting solution.

Which of the above options are best suited to elute the protein?

QUESTION ID:65

Marinomycin is a drug produced from

QUESTION ID:66

Saccharomyces cerevisiae was shown to ferment a carbon substrate to produce glycerol. It was observed that the supplementation of sodium sulfite into the medium led to enhanced glycerol production. What is the possible mode of action of sodium sulfite?

QUESTION ID:67

Which of the following bonds joins monomer subunits in biopolymers?

QUESTION ID:68

Severe combined immunodeficiency disorder is caused due to the loss of

QUESTION ID:69

Which of the following is NOT a form of the phytohormone auxin?

QUESTION ID:70

In the linkage map of three genes, A, B, and C, the distance between A and B is 7 cM, and B and C is 10 cM. The chiasma interference is 0.3. The percentage of progeny showing double crossing over will be

QUESTION ID:71

Which of the following contain introns in eukaryotes ?
A. Pre-mRNA
B. Mature mRNA
C. Mature miRNA
D. Genomic DNA

Choose the correct answer from the options given below

QUESTION ID:72

The movement of sunflower towards the sun is mainly controlled by which of the following?

QUESTION ID:73

Two globular proteins, A and B, have a molecular weight of 20 kDa each. Protein A is monomer, while B is a trimer. Which of the following is correct when gel-filtration chromatography is performed under native conditions ?

QUESTION ID:74

Match List I with List II: 
   List I (Plasmid)                     List II (Property) 
A. Promiscuous plasmid     I. Capable of replicating in a wide range of host 
B. Cryptic plasmid               II. Without any apparent functional coding gene 
C. Degradative plasmid     III. Carry specific set of genes for the utilization of unusual metabolite 
D. Phagemid                        IV. Hybrid formed between plasmid and bacteriophage 

Choose the correct answer from the option given below : 

QUESTION ID:75

Which of the following methods was used to sequence the human genome for the first time?

QUESTION ID:76

Given below are two statements :
Statement I : The standard streams: STDIN, STDOUT and STDERR are the typical I/0 facilities in programming languages like PERL.
Statement II : There are two families of programming languages: the C family and the Z family.

Choose the correct answer from the options given below :

QUESTION ID:77

Which of the following parameters is NOT used for scale-up of a bioreactor?

QUESTION ID:78

Given below are two statements :
Statement I : A chimeric mouse generated during transgenic mouse development has the genetic modification in the germ cells and needs no screening.
Statement II : A chimeric mouse generated during transgenic mouse development needs to be screened for the genetic modification in the germ cells.

Choose the correct answer from the options given below :

QUESTION ID:79

Penicillium sp. was grown aerobically to produce penicillin. It was observed that the filamentous cells became flexible after 10 h of growth. Which of the following explains the reason for enhanced filamentous flexibility?

QUESTION ID:80

Which of the following is an autoimmune disorder affecting peripheral nervous system ?

QUESTION ID:81

In which of the following partial diploids of the lac operon in E. coli, will there be constitutive expression of the structural genes ?
A. I+O+Z+Y+ | I+O+Z+Y+
B. I-O+Z+Y+ | I-O+Z+Y+
c. I-O+Z+Y+ | I+O+Z+Y+
D. I+OcZ+Y+ | I+OcZ+Y+

Choose the correct answer from the options given below :

QUESTION ID:82

From the given sets of enzymes active during Calvin-Benson cycle, identify the sets that are involved only during the regeneration phase of the cycle.
A. Phosphoglycerate kinase and triose-phosphate isomerase
B. Triose-phosphate isomerase and aldolase
C. Aldolase and phosphoribulokinase
D. Glyceraldehyde-3-phosphate dehydrogenase and fructose-1 ,6-bisphosphate
Choose the correct answer from the options given below :

QUESTION ID:83

The products of which of the following virulence (vir) genes activate transcription of other vir genes in Agrobacterium tumefaciens'? 

QUESTION ID:84

During anaerobic waste water treatment, the acetotrophs break down acetic acid Into

QUESTION ID:85

Match List I with List II :
  List I                                List II
A. T-test                        I. Random Forest
B. Bonferroni test        II. Central tendency
C. Machine learning   III. Molecular dynamics
D. Protein folding        IV. Multiple hypothesis

Choose the correct answer from the options given below

QUESTION ID:86

Which of the following patterns of mendelian inheritance are depicted in the pedigree chart given below ?


QUESTION ID:87

A bacterial culture is grown in a medium containing S35-labelled amino acids. Which of the following bacterial tetrapeptides will be radioactive ?

QUESTION ID:88

In BLAST search, the term "word size" refers to

QUESTION ID:89

RTS/S is a vaccine developed for prophylaxis of

QUESTION ID:90

Detection of cancerous tissue by positron emission tomography (PET) involves the injection of isotopically labeled glucose analog 2-fluro-2-deoxyglucose (FdG) into the patient followed by whole body imaging (CT scan). The principle behind this diagnostic system is that

QUESTION ID:91

TE buffer contains 200 mM Tris and 50 mM EDTA. If Tris and EDTA stock solutions are 1 M and 0.5 M, respectively, how much of each stock solution is required to make 100 ml of TE buffer?

QUESTION ID:92

Familial hypercholesterolemia is a genetic disorder characterized by high concentrations of cholesterol and low-density lipoprotein (LDL) in the plasma, about three to four times the desired amount. The molecular basis of the disease is

QUESTION ID:93

The gene therapy tools, Sleeping Beauty, Tol2, and PiggyBac are

QUESTION ID:94

Electron microscope has better resolution than light microscope. What is the reason for that?

QUESTION ID:95

If the absorbance at 260 nm of 1 :20 diluted RNA solution is 0.03, what is the concentration of RNA in the solution?

QUESTION ID:96

Different spectroscopy methods are used for the estimation of protein secondary structure and their dynamics. From the following, select the most appropriate method used for the estimation of secondary structure of the protein.

QUESTION ID:97

The following gel pattern was obtained, when a DNA molecule was sequenced using the Sanger sequencing method. Which of the following is the correct sequence of the template DNA?


QUESTION ID:98

Match List I with List II: 
  List I                   List II 
A. Sake         I. Fermented fish sauce 
B. Curd         II. Fermented milk product 
C. Garum     III. Non-distilled alcoholic beverage 
D. Paneer    IV. Coagulated milk product 

Choose the correct answer from the options given below : 

QUESTION ID:99

By some means, if you were able to decrease the Van der Waal's radii of atoms making up amino acids, what would be the effect of this change on the Ramachandran map of alanine in a dipeptide ?

QUESTION ID:100

Lidocaine hydrochloride (S = 0.87) drug was administered (1 mg/min) via intravenous route to a patient. His steady-state plasma concentration was found to be 3 mg/L. What should be the new infusion rate to achieve a desired steady-state plasma concentration of 4 mg/L ?

QUESTION ID:101

Influenza virus enters into the specific host cells by adhering to the cell-surface carbohydrates via one of the major proteins expressed on the surface of the virus. It is known as

QUESTION ID:102

Which of the following methods is best suited for the determination of distance between the active site and allosteric site of an enzyme ?

QUESTION ID:103

White matter is associated with which of the following structures ?

QUESTION ID:104

For the commercial production of secondary metabolites in plant tissue culture, phytoalexins are used as

QUESTION ID:105

Intrinsic fluorescence of proteins is dependent on

QUESTION ID:106

Alkanes are the main constituents of mineral oil contaminants. Alkanes are degraded by two pathways involving monooxygenase and dioxygenase enzymes. The end result of both pathways is the production of

QUESTION ID:107

Which of the following microorganisms is added to improve the flavor and assist eye formation in Swiss cheese ?

QUESTION ID:108

The root apical meristem comprises of meristematic zone, elongation zone and differentiation zone. Which of the following is NOT considered a part of the elongation zone ?

QUESTION ID:109

The first commercially released transgenic crop is

QUESTION ID:110

How many phosphodiester bonds are present in a DNA fragment of 36 nucleotides ?

QUESTION ID:111

An organism isolated from spoilage was found to have a Do value of 1.35 minutes. If initial spore load is 10 per can, what would be the required Fo of this canning process to achieve the probability of spoilage from this organism to be 1 in 100,000 ?

QUESTION ID:112

Which of the following is correct regarding the role of ribonucleotides during DNA replication?

QUESTION ID:113

Which of the following genetically engineered plant is approved for cultivation in India?

QUESTION ID:114

Low visibility during cold weather is due to

QUESTION ID:115

Which microscopy technique generates an image by transmitting a beam of electrons through a specimen, with the resulting image magnified and focused onto an imaging device such as photographic film or a CCO camera ?

QUESTION ID:116

Which of the following enzymes is commonly used in the clinical assay for estimating total blood glucose levels ?

QUESTION ID:117

Match List I with List II: 
  List I (Disease)                List II (Pathogen) 
A. Leprosy                      I. Bacillus anthracis 
B. Whooping cough     II. Mycobacterium leprae 
C. Anthrax                     III. Bordetella pertussis 
D. Syphilis                     IV. Treponema pallidum
 
Choose the correct answer from the option given below: 

QUESTION ID:118

In the lab, you are doing an experiment where you are growing E. coli in a growth medium with a heavy nitrogen (N15) as the only nitrogen source. After several generations, the same culture was switched to a medium containing light nitrogen (N14). The division was synchronized and after one generation of growth, DNA was isolated and centrifuged on a density gradient. What would you get ?

QUESTION ID:119

Match List I with List II: 

          List I                                             List II 

A. Aspergillus niger                        I. Production of citric acid

B. Saccharomyces cerevisiae       II. Fermentation of milk to produce yogurt 

C. Lactobacillus bulgaricus          III. Production of vinegar 

D. Acetobacter aerogenes           IV. Used in alcoholic fermentation 

 

Choose the correct answer from the options given below : 

QUESTION ID:120

A suspension containing 3 x 105 spores of A (D121.1°C = 1.5 minutes) and 8 x 106 spores of B (D121.1°C = 0.8 minutes) is uniformly heated at constant temperature of 121.1 °C. What will be the minimum time to obtain a probability of spoilage of 1/1000 for the suspension at these conditions?

QUESTION ID:121

Select the correct statements from the following regarding ultraviolet-visible spectroscopy and fluorescence spectroscopy.
A. Beer-Lambert law is applicable for the ultraviolet-visible spectroscopy.
B. Jablonski diagram is used in fluorescence spectroscopy.
C. Depending on stokes and anti-stokes shifts, fluorescent emission can have a longer or shorter wavelength than the exciting light.
D. Fluorescent light has a shorter wavelength than the exciting light.

Choose the correct answer from the options given below :

QUESTION ID:122

The buffer systems in the cytoplasm and in blood plasma, respectively, are

QUESTION ID:123

Following are certain statements regarding the interconversion of starch and sucrose at the onset of photosynthesis in plants.
A. Triose phosphates are accumulated in the chloroplast and subsequently transported to cytosol.
B. Inorganic phosphate (Pi) is transported to chloroplast from cytosol.
C. Triose phosphate activates while Pi inhibits the phosphofructokinase-2 enzyme in the cytosol.
D. Removal of Pi from cytosol activates sucrose-phosphate synthase enzyme.

Which of the above statements are true ?
Choose the correct answer from the options given below :

QUESTION ID:124

Match List I with List II: 
    List I (Chromatography)                                        List II (Buffer system) 
A. Ion Exchange chromatography                       I. Isocratic buffer 
B. Gel permeation chromatography                    II. Increasing salt gradient
C. Chromatofocussing                                          III. Reducing polarity of elution buffer
D. Hydrophobic interaction chromatography   IV. Buffer containing ampholytes 

Choose the correct answer from the options given below 

QUESTION ID:125

A FASTQ file contains
A. nucleotide sequence
B. quality score
C. protein sequence
D. functional annotation

Choose the correct answer from the options given below

QUESTION ID:126

Helicobacter pylori adhere to oligosaccharides on the surface of epithelial cells that line the inner surface of the stomach. Several fold greater incidences have been observed of gastric ulcers in people of blood type O than in those of type A or B, this is due to :

QUESTION ID:127

In the PDB, several structures of the same protein determined at different resolutions are available. Which of the structures (solved at below mentioned resolutions) is expected to provide the best atomic details ?

QUESTION ID:128

The first committed step of the glycolytic pathway is catalyzed by the enzyme

QUESTION ID:129

A diaphragm gauge in a stirred tank bioreactor is used to monitor

QUESTION ID:130

Which of the following processes may enhance cell flocculation ?
A. Neutralization of anionic charges
B. Reduction in surface hydrophilicity
C. Use of high molecular weight polymer bridges
D. High speed vortexing
E. Change in pH

Choose the correct answer from the options given below

QUESTION ID:131

Which of the following coenzyme functions as the reducing agent in fatty acid biosynthesis ?

QUESTION ID:132

Lock Jaw disease is caused by

QUESTION ID:133

What does BLAST stands for ?

QUESTION ID:134

In genome data analysis, Hidden Markov Models are widely used for

QUESTION ID:135

In the laboratory setting, you are provided with isolated intact mitochondria, and oxidizable substrates such as pyruvate or succinate. Addition of 02 and an oxidizable substrate to the isolated intact mitochondria results in a net synthesis of ATP. What can be normally expected, if a small amount of detergent is added to make the membranes leaky ?

QUESTION ID:136

Which of the following methods is NOT used to study DNA-protein interactions?

QUESTION ID:137

Which of the following is the most widely aqua cultured shrimp species in India?

QUESTION ID:138

Match List I with List II: 
 List I (Vector)          List II (Cloning Capacity) 
A. Cosmid                  I. Less than 10 kb 
B. BAC                       II. 20-45 kb 
C. YAC                       III. 100-300 kb 
D. Plasmid               IV. Greater than 500 kb 

Choose the correct answer from the option given below : 

QUESTION ID:139

You find a novel ORF overlapping with a known gene on the opposite strand. This could be an example of

QUESTION ID:140

What is the full form of GREACE employed widely for metabolic engineering of microbial strains?

QUESTION ID:141

The malo-lactic fermentation is desirable for improved quality of

QUESTION ID:142

A researcher is looking for a possible DNA binding region in a protein structure. It is most likely to be a

QUESTION ID:143

Which of the following statistical methods would you use to compare the means of two independent groups in a biological experiment ?

QUESTION ID:144

Deficiency of which of the following amino acids in the diet leads to insufficient synthesis of the vitamin niacin resulting in the disease Pellagra ?

QUESTION ID:145

The N50 of a given genome assembly is 500,000 bp. What does it mean ?

QUESTION ID:146

High serum level of urate (hyperuricemia) induces the painful joint disease gout. In human beings, urate is the final product of

QUESTION ID:147

Match List I with List II: 
       List I (Method)                                           List II (Principle) 
A. lon exchange chromatography            I. Stokes radius and size of molecules  
B. Affinity chromatography                       II. Structure and hydrophobicity of molecules 
C. Reverse phase chromatography          III. Biological function of molecules 
D. Gel filtration chromatography              IV. pl and charge distribution of molecules 

Choose the correct answer from the option given below: 

QUESTION ID:148

CATH is a hierarchical protein structure classification database. The letter "T' in the acronym stands for

QUESTION ID:149

Untreated diabetes mellitus and starvation are often associated with increased accumulation of acetyl-CoA, which accelerates the formation of

QUESTION ID:150

Match List I with List II: 
    List I                      List II 
A. Haploid             I. Tumor cells 
B. Diploid              II. Neurons 
C. Polyploid          III. Oocyte 
D. Aneuploid        IV. Trophoblasts
 
Choose the correct answer from the option given below : 

QUESTION ID:151

Which of the following biomolecules is NOT derived from amino acids?

QUESTION ID:152

For an enzyme catalyzed reaction following Michaelis-Menten kinetics with Vm = 12 mM h-1, substrate concentration equal to five times the value of its Km value, is used. What will be the initial reaction velocity (vi) of this reaction ?

QUESTION ID:153

You have a mixture of four proteins named B1 (55 kDa) , B2 (20 kDa), B3 (15 kDa) and B4 (10 kDa). Proteins B3 and B4 exist as strong heterodimer, while Bl and B2 are monomeric in solution. What will be the order of elution (first to last) of these proteins in a gel filtration column under isocratic conditions ?

QUESTION ID:154

In an ultracentrifugation experiment, two globular proteins, X and Y, sediment with S value (Svedberg units) of 1.8 and 5. 7, respectively. Which of the following statement is true ?

QUESTION ID:155

The decimal reduction time for sterilizing a culture media is 10 min. Calculate the specific death rate constant (min-1).

QUESTION ID:156

Which of the following is an immune checkpoint inhibitor for anti-cancer therapy?

QUESTION ID:157

Which posttranslational modification of lysine and proline is important for the stabilization of collagen structure ?

QUESTION ID:158

Which of the following statements is true about a competitive enzyme inhibition ?

QUESTION ID:159

What is the length of the polypeptide with 120 amino acid residues in a single contiguous a-helix?

QUESTION ID:160

Match List I with List II: 
    List I (Enzyme)                List II (Function) 
A. DNA polymerase-I          I. Joining of two ribonucleotide tri-phosphate molecules 
B. Helicase                           II. Removal of RNA primer 
C. DNA ligase                      III. Joining of two oligo-deoxyribonucleotides 
D. Primase                           IV. Unwinding of DNA 

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QUESTION ID:161

In which of the following tissues, translocation of solutes occur bidirectionally ?

QUESTION ID:162

Which of the following senses does NOT follow the 'receptor to thalamus to cortex' symmetry?

QUESTION ID:163

Which of the following plant growth regulators is routinely used for callus production ?

QUESTION ID:164

A microbial culture was grown in a batch reactor. However, an increase in pH was observed after exponential phase. The possible reason(s) for pH increase is/are
A. high residual glucose concentration in the media.
B. low residual glucose concentration in the media.
C. use of amino acids as carbon source.
D. catabolite repression.

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QUESTION ID:165

Which of the following cell organelles mainly contains the enzymes responsible for biosynthesis of membrane lipids?

QUESTION ID:166

Match List I with List II: 
     List I (Enzyme)                                   List II (Activity) 
A. Reverse transcriptase               I. DNA polymerase with no 5'-3' exonuclease activity 
B. Terminal transferase                 II. cDNA synthesis 
C. Klenow fragment                      III. Addition of poly-A tail at the 3'-end of mRNA 
D. T4 polynucleotide kinase         IV. Addition of a phosphate group at the 5'-end of synthetic oligonucleotide 

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QUESTION ID:167

Following are the statements regarding carbon assimilation in plants.
Assumption A: In Arabidopsis seedlings, glucose-insensitive (g/n2) mutant does not show developmental arrest phenotype in the presence of 6% glucose.
Reason R: The insensitivity towards glucose in gin2 mutant is due to the lack of hexokinase protein itself.

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QUESTION ID:168

Which of the following statements is true for critical dilution rate in continuous fermentation ?
A. It results in decrease in microbial cell density inside the reactor.
B. It results in increase in microbial cell density inside the reactor.
C. It does not influence microbial cell density inside the reactor.
D. It results in increase in residual substrate concentration inside the reactor.
E. It results in decrease in residual substrate concentration inside the reactor.

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QUESTION ID:169

The phi and psi angles of which of the following amino acid homopolymers will occur in all the four quadrants of its Ramachandran plot?

QUESTION ID:170

Transmission electron microscopy (TEM) involves different steps for sample preparation before visualization. Arrange the following steps in the right order of sample preparation.
A. Sectioning of sample by ultramicrotome
B. Embedding of sample by methyl methacrylate
C. Staining of sample by heavy metal
D. Dehydration of sample by ethanol-water mixture
E. Fixation of sample by formaldehyde

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QUESTION ID:171

Which of the following is used as an immunostimulant in aquaculture ?

QUESTION ID:172

Which of the following methods is used for hCG detection in the pregnancy test?

QUESTION ID:173

Based on a typical ABC model of flowering , which of the following statements are correct regarding the phenotype of the resultant flower from outer to inner whorl?
A. Loss of A function results into Carpel, Stamen, Stamen and Carpel.
B. Loss of A and B functions result into Carpel, Carpel, Carpel and Carpel.
C. Loss of C function results into Sepal, Sepal, Petal and Petal.
D. Loss of B function results into Sepal, Stamen, Carpel and Carpel.

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QUESTION ID:174

Which organelle is common in Nicotiana and Drosophila?

QUESTION ID:175

In RNA-seq data analysis, a gene is expressed at higher level in condition I with log2 fold-change of 8, as compared to condition II. What does it imply?

QUESTION ID:176

A new bacterium was isolated from the soil, which has rod shape and is positive in Gram's staining. The bacterium is unlikely to be ?

QUESTION ID:177

If the pH of an amino acid solution is below its pKa, it would exist as a/an

QUESTION ID:178

ABO blood type in humans exhibits codominance of multiple alleles. What is the likelihood of a Type A father and a Type A mother having a Type O child?

QUESTION ID:179

Human blood typing done in blood banks is based on

QUESTION ID:180

A continuous bioreactor produces 120 kg of lysine per day with a volumetric productivity of 0.4 gL-1h-1 . The working volume of the bioreactor is

QUESTION ID:181

Biosafety is an important aspect for safe handling of microbes and requires appropriate facilities. As a student, you are asked to work on anthrax culture in one such specialized laboratory. The appropriate defining feature of the facility to ensure safety will have:

QUESTION ID:182

Which of the following infectious agents do NOT have capsid proteins and move from cell to cell with the assistance of helper viruses ?

QUESTION ID:183

The bacterial growth curve in a batch culture has the following phases. Arrange the various phases of bacterial growth in the correct order.
A. Stationary phase
B. Lag phase
C. Log phase
D. Death phase

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QUESTION ID:184

Which of the following is NOT a protein domain database?

QUESTION ID:185

The enzyme involved in cholesterol biosynthesis that is inhibited by glucagon, AMPK and cholesterol is

QUESTION ID:186

Glyphosate resistance gene transferred into cotton, soybean, tomato and tobacco was obtained from

QUESTION ID:187

Which of the following is NOT a zoonotic disease ?

QUESTION ID:188

Which of the following peptides at 100 mM concentration will show maximum absorbance at 280 nm in UV-Visible spectroscopy?

QUESTION ID:189

Match List I with List II: 
   List I                              List II 
A. Okadaic acid          I. Bioluminescent jelly fish 
B. Manoalide              II. Dinoflagellate 
C. Aequorin                III. Red algae 
D. Phycoerythrin        IV. Marine sponge 

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QUESTION ID:190

When comparing multiple genomes, syntenic blocks are identified by

QUESTION ID:191

Which of the following organs is primarily responsible for metabolic regulation through gluconeogenesis and glycogenolysis?

QUESTION ID:192

Which of the following conditions will lead to the activation of gluconeogenesis pathway in the liver?

QUESTION ID:193

Which plant hormone promotes cell elongation ?

QUESTION ID:194

In biochemical reactions, the degree of reduction (γ) for ethanol (C2H5OH) will be

QUESTION ID:195

metabolic by product of sulphur-reducing bacteria is

QUESTION ID:196

In Golden Rice 2, the gene encoding phytoene synthase, the key player in carotenoid biosynthesis pathway, has been taken from

QUESTION ID:197

Which microbial strain is used for citric acid production ?

QUESTION ID:198

Nuclear Magnetic Resonance is used for three-dimensional structure determination of proteins. Which of the following is correct about NMR?

QUESTION ID:199

Match List I with List II: 
List I (Biosafety level)          List II (Organism) 
A. BSL 1                             I. Escherichia coli 
B. BSL 2                             II. Mycobacterium tuberculosis 
C. BSL 3                            III. Ebola 
D. BSL 4                            IV. Staphylococcus aureus 

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QUESTION ID:200

The antifreeze molecules that prevent intracellular ice formation in marine organisms are generally