Previous Year Questions

QUESTION ID:2

Choose the correct definitions:

(A) ‘Population density’ is population size in relation to some unit of space and time.

(B) ‘Natality’ is usually described in terms of the birth rate.

(C) ‘Mortality’ rate refers to the deaths occurred due to diseases.

(D) ‘Sex ratio’ refers to the number of ‘females’ relative to the number of ‘males’ in the population.

Choose the correct answer from the options given below:

QUESTION ID:3

Examples of non-renewable resources are :
(A) Coal
(B) Mineral oil
(C) Water used in industry
(D) Water used in domestic

Choose the correct answer :

QUESTION ID:4

actors that affect populations of a country are :
(A) Birth rate
(B) Death rate
(C) Emigration
(D) Immigration

Choose the correct answer :

QUESTION ID:5

In Mesosphere, temperature __________

QUESTION ID:6

Which element present in highest amount in the earth crust?

QUESTION ID:7

Laws governing Biodiversity Conservation in India.
(A) All India Elephant Preservation Act – 1879
(B) The Indian Forest Act – 1972
(C) The Indian Fisheries Act – 1897
(D) The Wild Life (Protection) Act – 1927

Choose the correct answer from the options given below :

QUESTION ID:8

Wild life protected areas in different states are given below :
(A) Tamil Nadu – Mudumalai
(B) Gujarat – Gir
(C) Kerala – Periyar
(D) Sikkim – Sunderban

Choose the correct answer :

QUESTION ID:9

Given below are two statements :

Statement I : The main sources of acid rains are oxides of Sulphur and nitrogen.
Statement II : Acid rain is responsible for stone leprosy.

In the light of the above statements, choose the most appropriate answer from the options :

QUESTION ID:10

Given below are two statements :

Statement I : Carbon dioxide, together with water vapor, is responsible for maintaining the earth’s atmosphere at a level that support life.

Statement II : About half of the total solar energy that strikes the earth is absorbed by the earth.

In the light of the above statements, choose the most appropriate answer from the options :

QUESTION ID:11

Match the following : 

Choose the correct answer from the options given below :

QUESTION ID:12

Biophotolysis in Oscillatoria is mediated by

QUESTION ID:13

Tobacco mosaic virus was discovered by

QUESTION ID:14

Prions, the small proteinaceous infectious particles were named by

QUESTION ID:15

Rubisco gets activated by light due to
(A) increase in pH of lumen
(B) decrease in pH of lumen
(C) decrease in pH of stroma
(D) increase in pH of stroma

Choose the correct answer from the options given below :

QUESTION ID:16

The entire process of electrons being displaced from PSI due to excitation by light, getting replaced from photosystem II and PS II obtaining the electrons from water is called

QUESTION ID:17

In allosteric regulation

QUESTION ID:18

The active site of an enzyme is flexible as per the

QUESTION ID:19

Free energy is

QUESTION ID:20

The difference between inside and outside hydrostatic pressure across the plasma membrane and cell wall is known as

QUESTION ID:21

Given below are two statements. One is labelled as Assertion (A) and the other is labelled as Reason (R).

Assertion (A): Some infection promote the development of autoimmune diseases.

Reason (R): Infectious microbes may contain antigens that cross-react with self-antigens.

In the light of the above statements, choose the most appropriate answer from the options given below :

QUESTION ID:22

The following steps are involved in characterization of antigens by Western Blotting :
(A) Electrophoretic transfer of proteins to membrane
(B) Separate protein antigen by SDS-poly acrylamide gel electrophoresis
(C) Denature proteins in the presence of SDS and apply to gel
(D) Label proteins in the membrane using a primary antibody specific for the antigen of interest
(E) Use antibody–labelled membrane with a substrate

Choose the correct answer:

QUESTION ID:23

The following steps are involved in the generation of antibodies specific for the T-cell receptor.

(A) Induce fusion of antigen specific T cells with long-lived T-cell line.
(B) Immunize mouse with the antigen, isolate the lymph nodes and culture with the antigen.
(C) Grow up individual clones of T-cell hybridomas that secrete IL-2 when stimulated with antigen specific peptides.
(D) Production of antibodies that bind T-cell receptor on the T-cell hybridoma.
(E) Identification of monoclonal antibody that interferes with the antigen recognition by T-cell hybridoma.

Choose the correct answer from the options given below :

QUESTION ID:24

Given below are two statements regarding vaccines :

Statement I : Vaccines are effective because of adaptive immunity and immune memory.

Statement II : Antibody memory exists in two compartments; first as pre-existing antibody and second as memory B-cells.

In the light of the above statements, choose the most appropriate answer from the options :

QUESTION ID:25

Given below are two statements regarding the generation of a vast array of B-cell receptors.

Statement I : Multiple gene segments encode the light chain.

Statement II : DNA recombination occurs in immunoglobulin genes in somatic cells.

In the light of the above statements, choose the correct answer from the options given below :

QUESTION ID:26

Given below are two statements regarding ubiquitination, binding of the carboxy terminal of ubiquitin to lysine residues of target proteins.

Statement I : Mono– or poly–ubiquitination serves as a mechanism by which the tagged proteins are targeted for destruction by the proteosome of the cell.

Statement II : Ubiquitination can serve as an activating signal by which the tagged proteins may form an activating complex.

In the light of the above statements, choose the correct answer from the options given below:

QUESTION ID:27

The following belong to the methods to enumerate and study functional responses of T cells. Match List I with List II. 

Choose the correct answer from the options given below:

QUESTION ID:28

Given below are two statements regarding T-cell receptor (TCR) affinity and selection :

Statement I : Fewer than 5% of thymocytes produce TCRs that bind to MHC-peptide complexes with high affinity. These will survive and mature.

Statement II : More than 90% of thymocytes produce TCRs that either do not bind to MHC/peptide complexes or bind them with very low affinity. These die by neglect.

Choose the most appropriate answer:

QUESTION ID:29

Only three of the proteins implicated in V(D)J recombination are unique to lymphocytes. One of the following proteins participates in the V(D)J recombination of antibody genes and is unique to the lymphocytes. Identify.

QUESTION ID:30

Given below are two statements. One is labelled as Assertion (A) and the other is labelled as Reason (R).

Assertion (A) : Type B T-cells would sneak through the negative selection process in the thymus.

Reason (R) : Thymic medullary epithelial cells or dendritic cells are uniquely capable of forming MHC class II–Insulin peptide from exogenous sources.

Choose the most appropriate answer:

QUESTION ID:31

QUESTION ID:32

Two hit origin of cancer i.e. both the alleles need to be inactivated for a gene to be inactive was first demonstrated/observed in 

QUESTION ID:33

Telomerase enzyme is activated only in

(A) Stem cells
(B) Differentiated somatic cells
(C) Cancer cells
(D) Muscle cells

Choose the correct answer from options:

QUESTION ID:34

In a Trisomic individual the number of chromosomes is

QUESTION ID:35

Which of the following is an epigenetic factor that controls gene expression at DNA level in eukaryotes?

QUESTION ID:36

What is the chemical modification of genome that is categorized as Imprinting process? 

QUESTION ID:37

Human Telomeres have multiple repeats of following sequences: 

QUESTION ID:38

A man identified with nervous system disease syndrome caused by mutation in mitochondrial DNA. He married female without any such abnormality and is healthy. What is the chance of offspring getting syndrome of father? 

QUESTION ID:39

In mitochondrial mutation associated with disease, the following two crossings were made

(i) mutant ♀ × wildtype ♂ → progeny?
(ii) wildtype ♀ × mutant ♂ → progeny?

What are the progeny phenotypes in these matings?

QUESTION ID:40

Mendel in his experiment did reciprocal crossing between two phenotypes – plants of purple flower with plant of white color. Reciprocal crossing produced in F₁ – All purple colors. By self crossing the F₁, the F₂ generation produces more of purple coloured flowers and few of white coloured flowers. From observation what you infer.

QUESTION ID:41

Two plant genotypes A/a ; b/b ; C/c ; D/d ; E/e. crossing with A/a B/b ; C/c ; d/d ; E/e. Assume the genes assort independently. How many progeny plant are required to screen a/a b/b c/c d/d e/e : (clue : Make separate crosses for each gene to get frequency of genotypes eg : Aa × Aa)

QUESTION ID:42

Meta genomics refers to

QUESTION ID:43

Which of the following statement is correct for Heterozygote advantage?

QUESTION ID:44

Which of the following is INCORRECT for mitochondrial disorders?

QUESTION ID:45

Which of the following options are correct for immunology?

(A) the immunoglobulin molecule is made up of six polypeptide chains
(B) the DNA encoding the ‘K’ light chain contains 4 distinct regions
(C) close relatives make the best organ donor because they are likely to share the same complement haplotypes
(D) The diversity of T cell surface antigen receptor can be compared with the process of immunoglobulin diversity

Choose the correct answer from options:

QUESTION ID:46

Which of the following statements are correct for sickle cell disease?

(A) Hbs differs from normal HbA by a single amino acid substitution
(B) The sickling effect of red blood corpuscles is the result of abnormal Hb binding with the red cell membrane
(C) Splenic infarction may occur but this has little clinical consequence
(D) Life-threatening thromboses can occur

Choose the correct answer from the options given below:

QUESTION ID:47

Which of the chemicals are used in the preparation of metaphase chromosomes for analysis of light microscopy?

(A) Phytohemagglutinin
(B) Quinacrine
(C) Colchicine
(D) Hypotonic saline

Choose the correct answer from the options given below:

QUESTION ID:48

Given below are two statements :

Statement I : In lyonization of X chromosome inactivation, all the genes of one X chromosome are switched off.

Statement II : In most phenotypic males with a karyotype of 46, XX, the SRY is present and found on one of the X chromosomes.

In the light of the above statements, choose the correct answer from the options :

QUESTION ID:49

Which of the methods can be used for gene therapy for cancer?

(A) Inhibition of fusion protein
(B) Stimulation of immune system
(C) Increased expression of the angiogenic factors
(D) RNA interference

Choose the correct answer from the options given below :

QUESTION ID:50

For pre-implantation genetic diagnosis (PGD) which of the following does not take place?