In this complex, Ci becomes phosphorylated in a series of steps catalyzed by PKA, GSK3β, and CK1.

TLS Online TPP Program

#Id: 10300

#Unit 4. Cell Communication and Cell Signaling

T-Cell Activation and Differentiation

TLS Online TPP Program

#Id: 10301

#Unit 4. Cell Communication and Cell Signaling

Three signals are required for activation of a naïve T cell

TLS Online TPP Program

#Id: 10302

#Unit 4. Cell Communication and Cell Signaling

Positive Costimulatory Receptors: ICOS

ICOS binds to another member of the growing B7 family, ICOS-ligand (ICOS-L), which is also expressed on a subset of activated APCs.

ICOS plays a key role in maintaining the activity of already differentiated effector and memory T cells.

TLS Online TPP Program

#Id: 10303

#Unit 4. Cell Communication and Cell Signaling

T-cell costimulatory

TLS Online TPP Program

#Id: 10304

#Unit 4. Cell Communication and Cell Signaling

Negative costimulation

TLS Online TPP Program

#Id: 10305

#Unit 4. Cell Communication and Cell Signaling

Anergy versus clonal expansion