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#Unit 2. Cellular Organization
The nuclear matrix and chromosome scaffold consist of different proteins, although there are some common components. Topoisomerase II is a prominent component of the chromosome scaffold, and is a constituent of the nuclear matrix, suggesting that the control of topology is important in both cases.
SATB1, is a protein that appears to regulate the association of MARs with the matrix in order to regulate transcription of genes in the vicinity of the MAR.