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TLS Online TPP Program

#Id: 1024

Intermediate levels of BMP effect the formation of the neural crest cells.

#Unit 5. Developmental Biology #Neural Tube Formation & Patterning #Part B Pointers
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TLS Online TPP Program

#Id: 1567

#Unit 4. Cell Communication and Cell Signaling

The central player in the “canonical” Wnt intracellular signal transduction pathway is called β-catenin.
TLS Online TPP Program

#Id: 1568

#Unit 4. Cell Communication and Cell Signaling

Homologs
β-catenin in vertebrates =Armadillo in Drosophila.
TLS Online TPP Program

#Id: 1569

#Unit 4. Cell Communication and Cell Signaling

“canonical” Wnt signaling pathway uses a second transmembrane protein, LRP that associates with Frizzled in a Wnt signal– dependent manner.
 
TLS Online TPP Program

#Id: 1570

#Unit 4. Cell Communication and Cell Signaling

Homologs
LRP in vertebrates = Arrow in Drosophila.
TLS Online TPP Program

#Id: 1571

#Unit 4. Cell Communication and Cell Signaling

In the absence of Wnts,
β-catenin is bound in a complex with Axin (a scaffold protein), APC, and kinases CK1 and GSK3.
TLS Online TPP Program

#Id: 1572

#Unit 4. Cell Communication and Cell Signaling

Kinases CK1 and GSK3,
sequentially phosphorylate β-catenin at multiple serine and threonine residues.