Allelic exclusion - Once allele’s functional protein is generated, rearrangement at the other allele is shut down

TLS Online TPP Program

#Id: 10508

#Unit 4. Cell Communication and Cell Signaling

CED-4 is a protease-activating factor that causes autoproteolytic cleavage of the CED-3 protease to promote its activation and to initiate cell death

TLS Online TPP Program

#Id: 10509

#Unit 4. Cell Communication and Cell Signaling

CED-4 in C. elegans = Apaf-1 in Mammals

TLS Online TPP Program

#Id: 10510

#Unit 4. Cell Communication and Cell Signaling

The principal caspase in C. elegans is CED-3

TLS Online TPP Program

#Id: 10511

#Unit 4. Cell Communication and Cell Signaling

CED-3 in C. elegans = Caspase-9 in mammals

TLS Online TPP Program

#Id: 10512

#Unit 4. Cell Communication and Cell Signaling

EGL-1 protein binds to CED-9, alters its conformation, and catalyzes the release of CED-4 from CED-9

TLS Online TPP Program

#Id: 10513

#Unit 4. Cell Communication and Cell Signaling

Four freed CED-4 dimers combine to form a CED-4 octamer, which binds two molecules of the CED-3 zymogen (an enzymatically inactive precursor) triggers the formation of the active CED-3 protease