TLS Online TPP Program

#Id: 2385

#Unit 3. Fundamental Processes

 Five ways to splice an RNA

TLS Online TPP Program

#Id: 2386

#Unit 3. Fundamental Processes

Steric Hindrance and Combinations of Major and Minor Splice Sites are major reasons behind alternative splicing (Mutually Exclusive Splicing) 

TLS Online TPP Program

#Id: 2387

#Unit 3. Fundamental Processes

Alternative splicing is often associated with weak splice sites.

TLS Online TPP Program

#Id: 2388

#Unit 3. Fundamental Processes

Specific exonic and intronic sequences can enhance or suppress splice site selection.

TLS Online TPP Program

#Id: 2389

#Unit 3. Fundamental Processes

In general, SR proteins bind to exonic splicing enhancers and the hnRNP proteins bind to exonic silencers

TLS Online TPP Program

#Id: 2390

#Unit 3. Fundamental Processes

Binding of SR proteins to ESEs promotes or stabilizes U1 binding to the 5’ splice site and U2AF binding to the 3’ splice site.