In secondary neurulation, 

the neural tube arises from the aggregation of mesenchyme cells into a solid cord that subsequently forms cavities that coalesce to create a hollow tube.

 

TLS Online TPP Program

#Id: 8860

#Unit 2. Cellular Organization

During S phase

DNA-bound G1 cohesins Convert into cohesive complexes by cohesin acetyl transferases (CoATs)

which acetylate Smc3 subunit & prevents unloading of cohesins by Pds5-Wapl, thereby stabilizing the cohesins on chromosomes.

TLS Online TPP Program

#Id: 8861

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8862

#Unit 2. Cellular Organization

In vertebrates, stabilization of cohesins requires the cohesin-associated factor sororin.

TLS Online TPP Program

#Id: 8863

#Unit 2. Cellular Organization

Defects of cohesin’s gene expression regulation function are the cause of a group of diseases collectively called cohesinopathies.

TLS Online TPP Program

#Id: 8864

#Unit 2. Cellular Organization

Defects of cohesin’s gene expression regulation function are the cause of a group of diseases collectively called cohesinopathies.

TLS Online TPP Program

#Id: 8865

#Unit 2. Cellular Organization

The phosphorylation state of T14 and Y15 is controlled by a dual-specificity protein kinase known as Wee1 and a pair of dual-specificity phosphatases, Cdc25B and Cdc25C (Threonine 14 is not phosphorylated in S. pombe CDK1)