B cells migrate to the lymphoid follicles. They are directed there by chemokine interactions between CXCL13, which is secreted by follicular dendritic cells (FDCs).

TLS Online TPP Program

#Id: 1627

#Unit 4. Cell Communication and Cell Signaling

Psoriasin Binds and sequesters divalent cations

TLS Online TPP Program

#Id: 1628

#Unit 4. Cell Communication and Cell Signaling

(C1s)2 are serine proteases, cleaves C4 and C2  has the same functions as Masp-1 and Masp-2.

TLS Online TPP Program

#Id: 1629

#Unit 4. Cell Communication and Cell Signaling

Alternative tickover pathway is initiated when C3 hydrolysed its internal thioester bond, yielding the molecule C3(H2O), in the presence of serum Mg2 binds another serum protein, factor B.

TLS Online TPP Program

#Id: 1630

#Unit 4. Cell Communication and Cell Signaling

C5b component is extremely labile, is not covalently bound to the membrane like C3b and C4b, and is rapidly inactivated unless it is stabilized by the binding of C6.

TLS Online TPP Program

#Id: 1631

#Unit 4. Cell Communication and Cell Signaling

C5b67 complexes can insert into the membrane of nearby cells and mediate “innocent bystander” lysis.

TLS Online TPP Program

#Id: 1632

#Unit 4. Cell Communication and Cell Signaling

C5b, C6 and C7 complex undergoes a conformational change that exposes hydrophobic regions on the surface of the C7 component capable of inserting into the interior of the microbial membrane.