Chromosomal translocation 

That brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene

TLS Online TPP Program

#Id: 8076

#Unit 13. Methods in Biology

CD can be used to estimate the structure of unknown proteins and monitor conformational changes due to temperature, mutations, heat, denaturants or binding interactions

TLS Online TPP Program

#Id: 8077

#Unit 13. Methods in Biology

CD spectra is used to

determine whether proteins are properly folded, 

estimate the fraction of the protein that is folded in either of the common secondary structures, and

monitor transitions between the folded and unfolded states.

TLS Online TPP Program

#Id: 8078

#Unit 13. Methods in Biology

TLS Online TPP Program

#Id: 8079

#Unit 13. Methods in Biology

α-helix has positive band at 190nm and negative bands at 222nm and 208nm.

TLS Online TPP Program

#Id: 8080

#Unit 13. Methods in Biology

UV CD is used to determine aspects of protein secondary structure.

Vibrational CD, IR CD, is used to study the structure of small organic molecules, proteins and DNA. 

TLS Online TPP Program

#Id: 8081

#Unit 13. Methods in Biology

Determination of the thermodynamics of folding and unfolding of proteins