CED-4 in C. elegans = Apaf-1 in Mammals

TLS Online TPP Program

#Id: 8930

#Unit 2. Cellular Organization

If the DNA damage is severe, p21 can cause the cells to senesce or p53 can induce apoptosis.

TLS Online TPP Program

#Id: 8931

#Unit 2. Cellular Organization

DNA-PK, ATM, and ATR phosphorylate a variant histone H2AX within the chromatin near the damage site & Phosphorylated H2AX acts as a landing pad for recruiting additional protein complexes that control DNA repair

TLS Online TPP Program

#Id: 8932

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8933

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8934

#Unit 2. Cellular Organization

Spindle assembly checkpoint pathway is active until every single kinetochore has attached properly to spindle microtubules

TLS Online TPP Program

#Id: 8935

#Unit 2. Cellular Organization