Extrinsic (death receptor–regulated) apoptosis pathway

binding of TNFα to TNFR1, a DD-containing death

receptor, recruits another two DD-containing

signaling molecules, TRADD and RIPK1

TLS Online TPP Program

#Id: 5283

#Unit 7. System Physiology – Animal

Stimulation of the sympathetic cardiac nerves speeds the depolarization in SA node.

TLS Online TPP Program

#Id: 5284

#Unit 7. System Physiology – Animal

The rate of spontaneous discharge increases Norepinephrine secreted by the sympathetic endings binds to β1 receptors

TLS Online TPP Program

#Id: 5285

#Unit 7. System Physiology – Animal

Increase in intracellular cAMP facilitates the opening of L channels, increasing ICa and the rapidity of the depolarization phase of the impulse.

TLS Online TPP Program

#Id: 5286

#Unit 7. System Physiology – Animal

When the cholinergic vagal fibers to nodal tissue are stimulated, the membrane becomes hyperpolarized and the slope of the prepotentials is decreased

TLS Online TPP Program

#Id: 5287

#Unit 7. System Physiology – Animal

Acetylcholine (ACh), released from parasympathetic nerve fibers, activates muscarinic (M2) receptors in the SA node.

TLS Online TPP Program

#Id: 5288

#Unit 7. System Physiology – Animal

Activation of the M2 receptors decreases cyclic adenosine 3′,5′-monophosphate (cAMP) in the cells, and this slows the opening of Ca 2+ channels.