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TLS Online TPP Program

#Id: 1143

Glomerulus is formed by the invagination of a tuft of capillaries into the dilated, blind end of the nephron (Bowman’s capsule).


#Unit 7. System Physiology – Animal #Renal Physiology #Part B Pointers
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TLS Online TPP Program

#Id: 8346

#Unit 2. Cellular Organization

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase
TLS Online TPP Program

#Id: 8347

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)
TLS Online TPP Program

#Id: 8348

#Unit 2. Cellular Organization

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)
TLS Online TPP Program

#Id: 8349

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8350

#Unit 2. Cellular Organization

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.
TLS Online TPP Program

#Id: 8351

#Unit 2. Cellular Organization

WASp activation requires two signals (This type of two-signal input, called coincidence detection):
1. regulatory phospholipid PIP2
2. small GTP-binding protein Cdc42