HER3 lacks a functional kinase domain

TLS Online TPP Program

#Id: 3134

#Unit 3. Fundamental Processes

The ability of a plasmid relying upon oriC to replicate in dam- E. coli depends on its state  of methylation.

TLS Online TPP Program

#Id: 3159

#Unit 3. Fundamental Processes

 Eukaryotic cells have many DNA polymerases. The replication enzymes operate with high fidelity. Except  for the β enzyme, the repair enzymes all have low fidelity.

TLS Online TPP Program

#Id: 3160

#Unit 3. Fundamental Processes

Replication enzymes have large structures, with separate subunits for different activities. Repair enzymes have much simpler structures.

TLS Online TPP Program

#Id: 3161

#Unit 3. Fundamental Processes

The conserved function of the replication components extends to the clamp loader and processivity clamp as well other functions of the replisome.

The roles of RFC and PCNA are analogous to the E. coli γ clamp loader and β2 processivity unit

TLS Online TPP Program

#Id: 3168

#Unit 3. Fundamental Processes

Three different DNA polymerases make up the eukaryotic replication fork

Pol α/rimase is responsible for primer synthesis on the lagging strand.

The MCM helicase (the eukaryotic homolog of Dna B ) unwinds the dsDNA, while 

PCNA (homolog of ex) endows the complex with processivity.

TLS Online TPP Program

#Id: 3169

#Unit 3. Fundamental Processes

Sequences that are involved with termination are called ter sites. A ter site contains a short, -23-bp sequence.