Characterization of the disease-causing deletion showed that the absence of two miRNAs, miR-15-a and miR-16-1, causes chronic lymphocytic leukemia (CLL)

TLS Online TPP Program

#Id: 9705

#Unit 4. Cell Communication and Cell Signaling

The receptors for yeast α and a mating factors are coupled to the same trimeric G protein.

TLS Online TPP Program

#Id: 9706

#Unit 4. Cell Communication and Cell Signaling

Ligand binding to either of the two yeast pheromone GPCRs triggers the exchange of GTP for GDP on the Gα subunit and dissociation of Gα∙GTP from the Gβγ complex.

TLS Online TPP Program

#Id: 9707

#Unit 4. Cell Communication and Cell Signaling

Ligand binding and dissociation of the G protein subunits, the membrane-tethered Gβγ subunit binds the Ste5.

TLS Online TPP Program

#Id: 9708

#Unit 4. Cell Communication and Cell Signaling

Ste5 acts as a scaffold for assembling other components in the cascade Ste11, Ste7, and Fus3.

TLS Online TPP Program

#Id: 9709

#Unit 4. Cell Communication and Cell Signaling

Gβγ activates Cdc24, a GEF for Cdc42

TLS Online TPP Program

#Id: 9710

#Unit 4. Cell Communication and Cell Signaling

Cdc24 = SOS

Cdc42 = Ras