The tetramerized p53 localize in nucleus for transcriptional activation.

TLS Online TPP Program

#Id: 8529

#Unit 2. Cellular Organization

Class IV IF proteins compose the neurofilaments found in neurons.

TLS Online TPP Program

#Id: 6136

#Unit 3. Fundamental Processes

XPC detect distortions = UvrA in E. coli

Formation of the bubble involves the helicase activities of the proteins XPA and XPD (the equivalent to UvrB in E. coli) and the single-strand-binding protein RPA. The bubble creates cleavage sites 5’ to the lesion for a nuclease known as ERCC1-XPF and 3’ to the lesion for nuclease XPG (representing the function of UvrC). In higher cells, the resulting DNA strand is 24–32 nucleotides long. As in bacteria, the DNA strand is released to create a gap that is filled in by the action of DNA polymerase and ligase.

XPB and XPD are both helicases; the XPB helicase is required for promoter melting during transcription, while the XPD helicase performs the unwinding function in NER

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#Id: 8197

#Unit 2. Cellular Organization

Zellweger syndrome

Autosomal recessive Mutations in any of a dozen different peroxins, the most common being Pex1, cause an impairment in peroxisomal protein import.

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#Id: 2191

#Unit 10. Ecological Principles

Secondary succession

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#Id: 7017

#Unit 5. Developmental Biology

Chemical regulation of stem cells takes the form of secreted proteins from surrounding cells that influence stem cell states and progenitor differentiation through endocrine, paracrine, or juxtacrine mechanisms.