P53 turned on  p2I/WAF-I, which binds to and inhibits the CDK/cyclin complexes for GI arrest

TLS Online TPP Program

#Id: 6152

#Unit 3. Fundamental Processes

Translesion synthesis is catalyzed by a specialized class of DNA polymerases that synthesize DNA directly across the site of the damage. In E. coli, DNA Pol IV (DinB) or DNA Pol V (a complex of the proteins UmuC and UmuD’) performs translesion synthesis.  DinB and UmuC are members of a distinct family of DNA polymerases found in many organisms known as the Y family of DNA 

polymerases. There are five translesion polymerases known in humans, four of which belong to the Y family.

TLS Online TPP Program

#Id: 6153

#Unit 3. Fundamental Processes

DinB and UmuC are members of a distinct family of DNA polymerases found in many organisms known as the Y family of DNA polymerases. There are five translesion polymerases known in humans, four of which belong to the Y family. 

TLS Online TPP Program

#Id: 6154

#Unit 3. Fundamental Processes

These polymerases are template-dependent, they incorporate nucleotides in a manner that is independent of base pairing.

TLS Online TPP Program

#Id: 6155

#Unit 3. Fundamental Processes

Human member of the Y family of translesion polymerases (DNA Pol n) correctly inserts two A residues opposite a thymine dimer. 

TLS Online TPP Program

#Id: 6156

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6157

#Unit 3. Fundamental Processes