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#Unit 3. Fundamental Processes
Under these conditions, a ribosome-associated protein called RelA receives the “alarm” and produces the “alarmone” ppGpp, which destabilizes open promoter complexes whose lifetimes are normally short, thus inhibiting Transcription.
The protein DskA binds to RNA polymerase and reduces the lifetimes of the rrn open promoters to a level at which they are responsive to changes in iNTP and ppGpp concentrations. Thus, DskA is required for the regulation of rrn transcription by these two small molecules.
