Kinesin-1  (similar to myosin II)

Head domain at the N-terminus of the heavy chain  

Stalk domain forms a long coiled-coil

Tail domain at C-terminus that attaches to cargo

TLS Online TPP Program

#Id: 8539

#Unit 2. Cellular Organization

The short (∼20 amino acid) C-terminal tails of both α- and β-tubulin that protrude from the microtubule are enriched in glutamic and aspartic acids, the surface of the microtubule possesses a net negative charge.

TLS Online TPP Program

#Id: 8540

#Unit 2. Cellular Organization

Dynein-related transport requires dynactin, that links dynein to its cargo

TLS Online TPP Program

#Id: 8572

#Unit 2. Cellular Organization

Soft keratins, or cytokeratins, are found in epithelial cells and make up the skin.

TLS Online TPP Program

#Id: 8573

#Unit 2. Cellular Organization

In all epithelia, keratin filaments associate with: Desmosomes (cell–cell contact)

Hemidesmosomes (cell–matrix contact)

TLS Online TPP Program

#Id: 8574

#Unit 2. Cellular Organization

when defective keratins are expressed in the basal cell layer of the epidermis, they produce a disorder called epidermolysis bullosa simplex

TLS Online TPP Program

#Id: 8575

#Unit 2. Cellular Organization

Vimentin, found in mesenchymal cells;

GFAP (glial fibrillary acidic protein), found in glial cells

Desmin, found in muscle cells