Cell migration mediated by the activation of the Wnt planar cell polarity pathway in the epiblast next to Koller’s sickle, at the posterior edge of the embryo.

TLS Online TPP Program

#Id: 6707

#Unit 3. Fundamental Processes

Cajal bodies are centers of RNP-complex assembly for spliceosomal snRNPs and other RNPs

TLS Online TPP Program

#Id: 6708

#Unit 3. Fundamental Processes

Conversion of specific uridine residues to pseudouridine and the addition of methyl groups to the 2′-hydroxyl groups

of specific riboses, that are important for the proper assembly and function of snRNPs in pre-mRNA splicing. 

These modifications occur in Cajal bodies, where they are directed by a class of snoRNA-like guide RNA molecules called scaRNAs (small Cajal body–associated RNAs)

TLS Online TPP Program

#Id: 6709

#Unit 3. Fundamental Processes

Cajal bodies are sites of reassembly of the U4/U6/U5 tri-snRNP complex from the free U4, U5, and U6 snRNPs released during the removal of introns from mRNAs

TLS Online TPP Program

#Id: 6710

#Unit 3. Fundamental Processes

p53 tumor suppressor protein appears to be post-translationally modified by phosphorylation and acetylation in PML nuclear bodies

TLS Online TPP Program

#Id: 6711

#Unit 3. Fundamental Processes

PML nuclear bodies are also sites of post-translational modification of proteins through the addition of a small, ubiquitin-like protein called SUMO1

TLS Online TPP Program

#Id: 6712

#Unit 3. Fundamental Processes