Toll protein surprisingly revealed that its cytoplasmic signaling domain was homologous to that of the vertebrate receptor for the cytokine IL-1 (IL-1R).

TLS Online TPP Program

#Id: 10503

#Unit 4. Cell Communication and Cell Signaling

In C. elegans BH3-only protein EGL-1 initiate apoptosis by binding to and inactivating CED-9

TLS Online TPP Program

#Id: 10504

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 protein = C. elegans CED-9 protein

(23% identical in aa sequence)

TLS Online TPP Program

#Id: 10505

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins act as regulators that suppress the apoptotic pathway

TLS Online TPP Program

#Id: 10506

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins contain a single TM domain and are localized to the outer mitochondrial membrane

TLS Online TPP Program

#Id: 10507

#Unit 4. Cell Communication and Cell Signaling

CED-9 protein, forms a complex with a dimer of the CED-4 protein, preventing the CED-4 protein from activating the CED-3 protease

TLS Online TPP Program

#Id: 10508

#Unit 4. Cell Communication and Cell Signaling

CED-4 is a protease-activating factor that causes autoproteolytic cleavage of the CED-3 protease to promote its activation and to initiate cell death