Site of DNA cleavage- Recombination Signal Sequence (RSS) 

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#Unit 4. Cell Communication and Cell Signaling

B- cell maturation

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#Unit 4. Cell Communication and Cell Signaling

T1 and T2 Transitional B Cells

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#Unit 4. Cell Communication and Cell Signaling

T1 cells are mIgMhi, mIgD -/lo, CD21-, CD23-, CD24+, and CD93+. 

T2 cells differ from T1 cells in having higher levels of mIgD and in expressing CD21 and CD23. 

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#Unit 4. Cell Communication and Cell Signaling

Transitional B cells bound for a follicular fate undergo positive and negative selection in the spleen.

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#Unit 4. Cell Communication and Cell Signaling

BAFF-R expression is first detected in T1 B cells and increases steadily there after.

Signaling through the BAFF/BAFF-R axis promotes survival of transitional B cells by inducing the synthesis of anti-apoptotic factors such as Bcl-2, Bcl-xl, and Mcl-1

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#Id: 10349

#Unit 4. Cell Communication and Cell Signaling