The serum half-life of IgE is quite short (only 2 to 3 days). However, when bound to its receptor on an innate immune cell, IgE is stable for weeks.

TLS Online TPP Program

#Id: 10486

#Unit 4. Cell Communication and Cell Signaling

MDM2 levels in the cytoplasm are controlled by

ATR and p14ARF (p19ARF in the mouse), sequesters it in the nucleolus, where it cannot access p53.

TLS Online TPP Program

#Id: 10487

#Unit 4. Cell Communication and Cell Signaling

Neoantigens are self-antigens generated by tumor cells because of genomic mutations, also derive from unique proteins or peptides produced by dysregulated RNA splicing and disordered post-translational protein modification

TLS Online TPP Program

#Id: 10488

#Unit 4. Cell Communication and Cell Signaling

Most tumor cells,express MHC class I molecules on their surface, cytotoxic T cells can directly recognize tumor cells expressing neo-antigens.

TLS Online TPP Program

#Id: 10489

#Unit 4. Cell Communication and Cell Signaling

Cytotoxic T cells release granules containing the proteins perforin and granzyme-B

TLS Online TPP Program

#Id: 10490

#Unit 4. Cell Communication and Cell Signaling

perforins punch holes in the endocytic vesicle membrane, allowing granzymes to enter the cytoplasm

TLS Online TPP Program

#Id: 10491

#Unit 4. Cell Communication and Cell Signaling