TLS Online TPP Program

#Id: 1764


Self antigens are not uncommon in the periphery, Two factors contribute to this:                                                                                                                             a. not all self a. antigens are expressed in the central lymphoid organs where negative selection occurs
b. there is a threshold requirement for affinity to self antigens before clonal deletion is triggered, allowing some weakly self-reactive clones to survive the weeding-out process.

#Unit 4. Cell Communication and Cell Signaling #Hypersensitivity and autoimmunity #Part B Pointers