Nurturing Life Sciences
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The Major Pathways of Complement Activation
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#Unit 2. Cellular Organization
Centromeric H3 (or CenH3) histone, known as Cse4 in yeast. CenH3 histones are incorporated into specialized nucleosomes present at centromeres.
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CenH3 has a unique N terminus, which does not resemble other core histones.
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Most H2A variants contain alternative C-termini, except H2ABbd, which contains a distinct N terminus.
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SpH2B has a long N-terminus and functions in Chromatin packaging
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In yeast, centromeric nucleosomes consist of Cse4, H4, and a nonhistone protein Scm3, in place of H2A-H2B dimers.
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In Drosophila, the centromeric chromatin appears to consist of “hemisomes” containing one copy each of CenH3, H4, H2A, and H2B.