TLS Online TPP Program

#Id: 5925

#Unit 3. Fundamental Processes

Sequences that are involved with termination are called ter sites. A ter site contains a short, 23-bp sequence.

TLS Online TPP Program

#Id: 5926

#Unit 3. Fundamental Processes

The termination sequences are unidirectional; that is, they function in only one orientation. The ter site is recognized by a unidirectional contrahelicase

TLS Online TPP Program

#Id: 5927

#Unit 3. Fundamental Processes

In E. coli, two clusters of five ter sites each, including terK, -I, -E, -D, and -A on one side and terC, -B, -F, -G, and -H on the other, are located 100 kb on either side of this termination region.

Each set of ter sites is specific for one direction of fork movement

TLS Online TPP Program

#Id: 5991

#Unit 3. Fundamental Processes

Eukaryotic replication is similar in most aspects to bacterial replication. It is semiconservative, bidirectional, and semidiscontinuous.

TLS Online TPP Program

#Id: 5992

#Unit 3. Fundamental Processes

Eukaryotic replicons are 40 to 100 kb in length and individual replicons are activated at characteristic times during S phase.

TLS Online TPP Program

#Id: 5993

#Unit 3. Fundamental Processes

Replicons in euchromatin initiate before replicons in heterochromatin