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TLS Online TPP Program

#Id: 2292

Isomerization is essentially irreversible and once complete, typically guarantees that transcription will subsequently initiate .

#Unit 3. Fundamental Processes #Eukaryotic transcription factors and machinery #Part B Pointers
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TLS Online TPP Program

#Id: 6537

#Unit 7. System Physiology – Animal

The influx of Ca2+ ions raises, triggering the fusion of insulin- containing secretory vesicles with the plasma membrane and the secretion of insulin
TLS Online TPP Program

#Id: 6538

#Unit 7. System Physiology – Animal

The insulin receptor, a receptor tyrosine kinase, activates several signal transduction pathways, including the one leading to the activation of protein kinase B
TLS Online TPP Program

#Id: 6539

#Unit 7. System Physiology – Animal

The insulin receptor is a combination of four subunits held together by disulfide linkages: 
Two alpha subunits 
Two beta subunits
TLS Online TPP Program

#Id: 6540

#Unit 7. System Physiology – Animal

The binding of insulin is communicated through the single TM helix of each beta subunit to the paired Tyr kinase domains inside the cell, activating them to phosphorylate each other on three Tyr residues (Tyr1158, Tyr1162, Tyr1163)
TLS Online TPP Program

#Id: 6541

#Unit 7. System Physiology – Animal
TLS Online TPP Program

#Id: 6542

#Unit 7. System Physiology – Animal

Fat and muscle cells express large amounts of the insulin-responsive glucose transporter GLUT4