Pointers

TLS Online TPP Program

#Id: 2333

Thus, although the aNTD is embedded in the body of the enzyme, the aCTD can reach the upstream element and can do so even when that element is not located immediately adjacent to the –35 region, but further upstream.

#Unit 3. Fundamental Processes #Elongation #Part B Pointers

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TLS Online TPP Program

#Id: 8459

#Unit 1. Molecules and their Interaction Relevant to Biology

Five types of constraints affect the stability of an helix:

(1) the intrinsic propensity of an amino acid residue to form an helix;

(2) the interactions between R groups, particularly those spaced three (or four) residues apart;

(3) the bulkiness of adjacent R groups;

(4) the occurrence of Pro and Gly residues; and

(5) interactions between amino acid residues at the ends of the helical segment and the electric dipole inherent to the helix.

TLS Online TPP Program

#Id: 8460

#Unit 1. Molecules and their Interaction Relevant to Biology

The intrinsic propensity of an amino acid residue to form an helix

TLS Online TPP Program

#Id: 8461

#Unit 1. Molecules and their Interaction Relevant to Biology

The interactions between R groups, particularly those spaced three (or four) residues apart; The assembly is said to have a coiled coil structure because each α helix itself follows a helical path.

TLS Online TPP Program

#Id: 8462

#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 8463

#Unit 1. Molecules and their Interaction Relevant to Biology

Interactions between amino acid residues at the ends of the helical segment and the electric dipole inherent to the helix.

TLS Online TPP Program

#Id: 8464

#Unit 1. Molecules and their Interaction Relevant to Biology

The overall effect is a significant net dipole for the a helix that gives a partial positive charge at the amino end and a partial negative charge at the carboxy end of the a helix.