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TLS Online TPP Program

#Id: 2379


Prp8, a large scaffold protein that directly contacts both the 5’ and 3’ splice sites within the spliceosome.


#Unit 3. Fundamental Processes #Splicing #Part B Pointers
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TLS Online TPP Program

#Id: 8389

#Unit 2. Cellular Organization

Smooth muscle contraction is regulated by the cycling of myosin II between on and off states.

TLS Online TPP Program

#Id: 8390

#Unit 2. Cellular Organization

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.


TLS Online TPP Program

#Id: 8391

#Unit 2. Cellular Organization

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 8392

#Unit 2. Cellular Organization

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC. 

TLS Online TPP Program

#Id: 8393

#Unit 2. Cellular Organization

Phosphorylation of MLC 
unfolds the myosin II, active and can assemble into bipolar filaments for contraction


TLS Online TPP Program

#Id: 8394

#Unit 2. Cellular Organization

When the Ca2+ levels drop:
Myosin LC is dephosphorylated by MLC phosphatase, causing muscle relaxation.


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