A. G. Tiselius (1937) Performed Moving boundary electrophoresis  in a U-shaped tube using Schlieren optics on both end for Measurements of the electrophoretic mobilities.

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#Unit 2. Cellular Organization

Cot1/2 is concentration of ssDNA left after time t. T1/2 is time taken for half renaturation.

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#Unit 2. Cellular Organization

Low Cot1/2 value means

1. Low complexity with high repeats

2. High complexity with high repeats

3. Low complexity with no repeats

4. no complexity and no repeats

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#Unit 2. Cellular Organization

Number of Genes present in per million base pair of genome is called gene density.

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#Unit 2. Cellular Organization

Escherichia coli K-12 is 4.6Mb genome with 4400 genes so gene density 950 genes/Mb.

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#Unit 2. Cellular Organization

Homo sapiens has 3200 Mb genome in which 20,000 genes are present so Gene density will be 6.25 genes/Mb.

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#Unit 2. Cellular Organization

Gene density has inverse relation with complexity of genome.