The original template sequence will also be copied during the second and all subsequent cycles to generate the 'long product'. Therefore, the long product continues to increase linearly, while the 'correct PCR' product will multiply exponentially. 

TLS Online TPP Program

#Id: 5784

#Unit 7. System Physiology – Animal

Basolateral membranes of thyrocytes contain a symporter Na+/I –symporter (NIS) 

TLS Online TPP Program

#Id: 5785

#Unit 7. System Physiology – Animal

Process of concentrating the iodide in the cell is called iodide trapping

TLS Online TPP Program

#Id: 5786

#Unit 7. System Physiology – Animal

Na+/I – symporter (NIS) is capable of producing intracellular I – concentrations that are 20– 40 times as great as the concentration in plasma

TLS Online TPP Program

#Id: 5787

#Unit 7. System Physiology – Animal

Wolff –Chaikoff effect large doses of iodide act directly on the thyroid to produce a mild and transient inhibition of organic binding of iodide and hence of hormone synthesis.

TLS Online TPP Program

#Id: 5788

#Unit 7. System Physiology – Animal

Thyroid stimulating hormone induces both NIS expression and the retention of NIS in the basolateral membrane.

TLS Online TPP Program

#Id: 5789

#Unit 7. System Physiology – Animal

Iodide is transported out of the thyroid cells across the apical membrane into the follicle by a chloride-iodide ion counter- transporter molecule called pendrin.