Touchdown PCR, has been devised to increase the specificity of PCR without lowering the efficiency.

 

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#Id: 10449

#Unit 4. Cell Communication and Cell Signaling

Human papillomavirus encodes two oncogenic proteins: E6 -inhibits p53

E7- inhibits RB

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#Id: 10450

#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That fuses two genes together to produce a hybrid gene encoding a chimeric protein whose activity is constitutive

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#Id: 10451

#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene

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#Id: 10452

#Unit 4. Cell Communication and Cell Signaling

Philadelphia chromosome generated by a translocation

between chromosomes 22 and 9

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#Id: 10453

#Unit 4. Cell Communication and Cell Signaling

Translocation between chromosomes 22 and 9 form new oncogenic fusion protein - BCR-ABL hybrid protein kinase

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#Id: 10454

#Unit 4. Cell Communication and Cell Signaling

BCR-ABL fusion protein is a constitutively active

kinase that phosphorylates multiple signal-transducing proteins.