Lane 3 depicts the behavior of the same DNA bound to two proteins. The mobility is reduced still further because of the greater mass of protein clinging to the DNA. This is 

called a supershift. 

TLS Online TPP Program

#Id: 1756

#Unit 4. Cell Communication and Cell Signaling

Class I presentation requires internal synthesis of virus protein, as shown by the requirement that the target cell be infected by live virus, and by the inhibition of class I presentation observed when protein synthesis was blocked by the inhibitor emetine.

TLS Online TPP Program

#Id: 1757

#Unit 4. Cell Communication and Cell Signaling

Class II presentation can occur with either live or replication-incompetent virus; protein synthesis inhibitors had no effect, indicating that new protein synthesis is not a necessary condition of class II presentation.

TLS Online TPP Program

#Id: 1758

#Unit 4. Cell Communication and Cell Signaling

Class II, but not class I, presentation is inhibited by treatment of the cells with an agent that blocks endocytic processing within the cell (chloroquine).

TLS Online TPP Program

#Id: 1759

#Unit 4. Cell Communication and Cell Signaling

Mechanisms to protect an individual from this sort of anti-self immune attack must exist, and they do, called as tolerance

TLS Online TPP Program

#Id: 1760

#Unit 4. Cell Communication and Cell Signaling

Self-tolerance involving both the elimination of immune cells that can react against self-antigens and active inhibition of immune responses.

TLS Online TPP Program

#Id: 1761

#Unit 4. Cell Communication and Cell Signaling

Self-reactive B cells can undergo receptor editing.

In this process, the antigen-specific V region is “edited” or switched for a different V-region gene segment via V(D)J recombination,