In yeast, the combined action of Cdc6, Cdtl, and the MCM proteins provides the licensing function.

TLS Online TPP Program

#Id: 9968

#Unit 4. Cell Communication and Cell Signaling

“canonical” Wnt signaling uses a second TM protein, LRP that associates with Frizzled in a Wnt signal– dependent manner.

TLS Online TPP Program

#Id: 2298

#Unit 3. Fundamental Processes

The transition from the closed to the open complex involves structural changes in the enzyme and the opening of the DNA double helix to reveal the template and nontemplate strands. This “melting” occurs between positions –11 and +2, with respect to the transcription start site.

TLS Online TPP Program

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#Unit 2. Cellular Organization

In contrast, there is another category of heterochromatin, called facultative heterochromatin, in which regions of euchromatin are converted to a heterochromatic state.

TLS Online TPP Program

#Id: 6880

#Unit 3. Fundamental Processes

Modification of H2A inhibits elongation by inhibiting a histone chaperone that removes histone octamers from DNA as Pol II transcribes through a nucleosome, then replaces them as the polymerase passes. 

TLS Online TPP Program

#Id: 639

#Unit 3. Fundamental Processes

The +vely charged acridine dyes or acridine orange are potent mutagens that induce frameshift mutations by Intercalation.