The gap is filled by DNA polymerase I; pol A mutants fail to join their Okazaki fragments properly. 

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#Unit 4. Cell Communication and Cell Signaling

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#Unit 4. Cell Communication and Cell Signaling

Chromothripsis

entire chromosomes or large parts of chromosomes are shattered and stitched together, leading to dozens or sometimes even hundreds of rearrangements

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#Unit 4. Cell Communication and Cell Signaling

Warburg effect

Cancer cells and proliferating cells convert most glucose to lactate regardless of whether oxygen is present or not. 

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#Unit 4. Cell Communication and Cell Signaling

Warburg effect

The production of lactate in the presence of oxygen is called aerobic glycolysis

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#Unit 4. Cell Communication and Cell Signaling

Cancer- specific metabolite

2-Hydroxyglutarate produce by mutated IDH

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#Id: 10413

#Unit 4. Cell Communication and Cell Signaling

Angiogenesis

The developmental process for the formation of blood vessels that are needed to supply nutrients to a growing tumor