Nurturing Life Sciences
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#Unit 2. Cellular Organization
formin family members have two adjacent domains:
FH1- rich in proline, landing site for profilin–ATP–G-actin
FH2 - form a dimer and nucleate filament assembly
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Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase
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To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)
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The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)
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