Chemical carcinogens classified into two general categories:
1. Direct-acting carcinogens
2. Indirect-acting carcinogens

TLS Online TPP Program

#Id: 6673

#Unit 3. Fundamental Processes

Splice sites are directional in nature. 5’ splice site -the left, or donor, site and the 3’ splice site - right, or acceptor, site

TLS Online TPP Program

#Id: 6674

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6675

#Unit 3. Fundamental Processes

Lariat formation is characterize by 2’-5’ phosphodiester bond Prp8, a large scaffold protein that directly contacts both the 5’ and 3’ splice sites within the spliceosome.

TLS Online TPP Program

#Id: 6676

#Unit 3. Fundamental Processes

Prp5 is critical for U2 binding

Brr2 facilitates U1 and U4 release

Prp2 is responsible for the activation of the spliceosome Prp22 helps the release of the mature mRNA from the spliceosome

TLS Online TPP Program

#Id: 6677

#Unit 3. Fundamental Processes

Prp22 helps the release of the mature mRNA from the spliceosome, makes splicing irreversible.

TLS Online TPP Program

#Id: 6678

#Unit 3. Fundamental Processes

Group II mitochondrial introns are excised by the same mechanism as nuclear pre-mRNAs via a lariat that is held together by a 2’–5’ bond.