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TLS Online TPP Program

#Id: 3249

The presence of the bromo substituent allows the base to mispair with guanine via the enol tautomer


#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 8589

#Unit 2. Cellular Organization

Lamins are reversibly disassembled by phosphorylation during mitosis
TLS Online TPP Program

#Id: 8590

#Unit 2. Cellular Organization

Mitotic CDKs drive phosphorylation of lamins A, B, and C results in disassembly of the intermediate filament lattice into lamin dimers.
TLS Online TPP Program

#Id: 8591

#Unit 2. Cellular Organization

Due to C-terminal prenylation of lamin B, 
lamin B dimers remain associated with the nuclear
membrane
TLS Online TPP Program

#Id: 8592

#Unit 2. Cellular Organization

During telophase, de-phosphorylation by specific phosphatases promotes lamin reassembly, which is critical to re-formation of a nuclear envelope around the daughter chromosomes.
TLS Online TPP Program

#Id: 8593

#Unit 2. Cellular Organization

Laminopathies 
Mutation in lamin A
TLS Online TPP Program

#Id: 8594

#Unit 2. Cellular Organization

Emery-Dreifuss muscular dystrophy (EDMD)
mutations in emerin, a nesprin and a SUN protein