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TLS Online TPP Program

#Id: 3291


In BER, The nick remaining after DNA polymerase I has dissociated is sealed by DNA ligase.

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 10083

#Unit 4. Cell Communication and Cell Signaling

The α subunit of each integrin is the primary determinant of its extracellular ligand specificity

TLS Online TPP Program

#Id: 10084

#Unit 4. Cell Communication and Cell Signaling

Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.

TLS Online TPP Program

#Id: 10085

#Unit 4. Cell Communication and Cell Signaling

I-domains also recognize CAMs on other cells, 
ICAMs, VCAMs and participate in cell-cell adhesion.

TLS Online TPP Program

#Id: 10086

#Unit 4. Cell Communication and Cell Signaling

The non-I-domain α subunits recognize RGD motif.

TLS Online TPP Program

#Id: 10087

#Unit 4. Cell Communication and Cell Signaling

TGF-β1 and TGF-β3 contain RGD motif that binds to integrins.

TLS Online TPP Program

#Id: 10088

#Unit 4. Cell Communication and Cell Signaling

Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.

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