If 10 protons are pumped out per NADH and 4 must flow in to produce 1 ATP, the proton-based P/O ratio is 2.5 for NADH as the electron donor and 1.5 (6/4) for succinate.

TLS Online TPP Program

#Id: 5536

#Unit 7. System Physiology – Animal

The thin segment of the ascending limb has a much lower reabsorptive capacity than does the thick segment.

TLS Online TPP Program

#Id: 5537

#Unit 7. System Physiology – Animal

Thick segment of the ascending limb of loop of Henle, has thick epithelial cells that have high metabolic activity and are capable of active reabsorption of sodium, chloride, and potassium

TLS Online TPP Program

#Id: 5538

#Unit 7. System Physiology – Animal

In the thick segment of the ascending loop of Henle  reabsorption mechanism is load-dependent.

TLS Online TPP Program

#Id: 5539

#Unit 7. System Physiology – Animal

In the thick ascending loop,  Luminal membrane contains a three-ion cotransporter  known as Na+-K+-2Cl- cotransporter

TLS Online TPP Program

#Id: 5540

#Unit 7. System Physiology – Animal

Thick ascending limb is called the diluting segment because NaCl is reabsorbed but water is not reabsorbed along with it 

TLS Online TPP Program

#Id: 5541

#Unit 7. System Physiology – Animal

The Cl – moves into the interstitium via ClC-Kb channels & Barttin, a protein in the cell membrane, is essential for normal ClC-Kb

function